Phenotypes associated with this allele

• Allele Symbol: Thrsp^tm1Cnm
• Allele Name: targeted mutation 1, Cary N Mariash
• Allele ID: MGI:2387689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrsp^tm1Cnm/Thrsp^tm1Cnm	B6.129-Thrsp^tm1Cnm	MGI:3770054

Genotype
MGI:3770054

hm1

• Allelic Composition: Thrsp^tm1Cnm/Thrsp^tm1Cnm
• Genetic Background: B6.129-Thrsp^tm1Cnm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:129452 )

♀ • de novo lipid biosynthesis in lactating mammary glands is reduced 62% compared to in wild-type mice

♀ • however, de novo lipid biosynthesis in the liver is normal

decreased triglyceride level ( J:129452 )

• triglyceride levels are reduced by 33% compared to in wild-type mice

• medium-chain fatty are reduced compared to in wild-type mice (10:0, 12:0, and 14:0 fatty acids are reduce more than 80%; 16:0 fatty acids are reduced 59%)

endocrine/exocrine glands

abnormal lactation ( J:129452 )

♀ • neonatal weights of mice nursed is less than those nursed by wild-type dams starting at day 7

abnormal milk composition ( J:129452 )

♀ • triglyceride level in dam curd reduced by 28% compared to in wild-type mice

♀ • however, protein content is normal

integument

abnormal lactation ( J:129452 )

♀ • neonatal weights of mice nursed is less than those nursed by wild-type dams starting at day 7

abnormal milk composition ( J:129452 )

♀ • triglyceride level in dam curd reduced by 28% compared to in wild-type mice

♀ • however, protein content is normal