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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slatm1Weis
targeted mutation 1, Arthur Weiss
MGI:2387691
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slatm1Weis/Slatm1Weis involves: 129 * C57BL/6 MGI:3033124
cx2
 		Slatm1Weis/Slatm1Weis
Sla2tm1Amch/Sla2tm1Amch 		involves: 129 MGI:4941875
cx3
 		Slatm1Weis/Slatm1Weis
Zap70tm1Weis/Zap70tm1Weis 		involves: 129 * 129X1/SvJ * C57BL/6 MGI:3033126
cx4
 		Slatm1Weis/Slatm1Weis
Tg(DO11.10)10Dlo/0 		involves: 129 * BALB/c * C3H * C57BL/6 MGI:3033125


Genotype
MGI:3033124
hm1
Allelic
Composition		 Slatm1Weis/Slatm1Weis
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slatm1Weis mutation (1 available); any Sla mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-positive T cell morphology ( J:71804 )
• upregulation of T cell receptor, CD4, CD5, CD8, and CD69 expression on double-positive thymocytes
• such upregulation was not observed with mature T cells in the periphery

immune system
abnormal double-positive T cell morphology ( J:71804 )
• upregulation of T cell receptor, CD4, CD5, CD8, and CD69 expression on double-positive thymocytes
• such upregulation was not observed with mature T cells in the periphery




Genotype
MGI:4941875
cx2
Allelic
Composition		 Slatm1Weis/Slatm1Weis
Sla2tm1Amch/Sla2tm1Amch
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sla2tm1Amch mutation (1 available); any Sla2 mutation (25 available)
Slatm1Weis mutation (1 available); any Sla mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
abnormal dendritic cell physiology ( J:169170 )
• bone marrow-derived dendritic cells treated with LPS and incubated with CD3-enriched cells elicit less T cell proliferation compared with similarly treated wild-type cells
• bone marrow-derived dendritic cells treated with LPS and pulsed with ovalbumin fail to induce increased production of IFN-gamma from Tg(DO11.10)10Dlo T cells compared with similarly treated wild-type cells
decreased interleukin-12 secretion ( J:169170 )
• in bone marrow-derived dendritic cells grown in LPS, GM-CSF alone, or GM-CSF with IL4
decreased tumor necrosis factor secretion ( J:169170 )
• in LPS-treated bone marrow-derived dendritic cells

hematopoietic system
hematopoietic system phenotype ( J:169170 )
N
• mice exhibit normal hematological parameters
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation

cellular
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation




Genotype
MGI:3033126
cx3
Allelic
Composition		 Slatm1Weis/Slatm1Weis
Zap70tm1Weis/Zap70tm1Weis
Genetic
Background		 involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slatm1Weis mutation (1 available); any Sla mutation (21 available)
Zap70tm1Weis mutation (2 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:71804 )
• partial rescue of block at double-positive stage observed in Zap70tm1Weis homozygotes
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
decreased CD4-positive, alpha-beta T cell number ( J:71804 )
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type

hematopoietic system
abnormal T cell differentiation ( J:71804 )
• partial rescue of block at double-positive stage observed in Zap70tm1Weis homozygotes
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type
decreased CD4-positive, alpha-beta T cell number ( J:71804 )
• thymocytes mature to the single-positive stage and proceed to become mature T cells, but overall number of mature CD4+ T cells is less than that of wild-type




Genotype
MGI:3033125
cx4
Allelic
Composition		 Slatm1Weis/Slatm1Weis
Tg(DO11.10)10Dlo/0
Genetic
Background		 involves: 129 * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slatm1Weis mutation (1 available); any Sla mutation (21 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:71804 )
• enhanced positive selection, resulting in an increase in the number of cells that mature to the single positive stage relative to wild-type

immune system
abnormal positive T cell selection ( J:71804 )
• enhanced positive selection, resulting in an increase in the number of cells that mature to the single positive stage relative to wild-type




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory