About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		St3gal1tm1Jxm
targeted mutation 1, Jamey Marth
MGI:2387752
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Clec10atm1Hed/Clec10atm1Hed
St3gal1tm1Jxm/St3gal1tm1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3850151
cx2
 		Clec10atm1Hed/Clec10a+
St3gal1tm1Jxm/St3gal1tm1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3850152


Genotype
MGI:3850151
cx1
Allelic
Composition		 Clec10atm1Hed/Clec10atm1Hed
St3gal1tm1Jxm/St3gal1tm1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec10atm1Hed mutation (3 available); any Clec10a mutation (23 available)
St3gal1tm1Jxm mutation (0 available); any St3gal1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• although at 3 and 5 weeks of age, female (but not male) double homozygotes show a significant increase of CD8-positive T-cell numbers in the periphery relative to mice that are heterozygous for Mgl1tm1Hed and homozygous for St3gal1tm1Jxm, double homozygotes still exhibit a profound CD8 T-cell deficiency relative to wild-type mice

immune system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• although at 3 and 5 weeks of age, female (but not male) double homozygotes show a significant increase of CD8-positive T-cell numbers in the periphery relative to mice that are heterozygous for Mgl1tm1Hed and homozygous for St3gal1tm1Jxm, double homozygotes still exhibit a profound CD8 T-cell deficiency relative to wild-type mice




Genotype
MGI:3850152
cx2
Allelic
Composition		 Clec10atm1Hed/Clec10a+
St3gal1tm1Jxm/St3gal1tm1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec10atm1Hed mutation (3 available); any Clec10a mutation (23 available)
St3gal1tm1Jxm mutation (0 available); any St3gal1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• at 3 to 6 weeks of age, mutant mice exhibit a variable reduction in the percentage of CD8 T cells in peripheral blood relative to heterozygous St3gal1tm1Jxm control mice (1-5% vs 11%, respectively)

immune system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• at 3 to 6 weeks of age, mutant mice exhibit a variable reduction in the percentage of CD8 T cells in peripheral blood relative to heterozygous St3gal1tm1Jxm control mice (1-5% vs 11%, respectively)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory