Analysis Tools
behavior/neurological
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• mice fail to exhibit as substantial of an increase in locomotor activity during dark phase as in wild-type mice when exposed to a novel environment
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• at night, mice consume less water than wild-type mice due to reduced duration of wake time
• initially, upon waking, mice consume more water than wild-type mice
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• at night, mice consume less food than wild-type mice due to reduced duration of wake time
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• at night, mice exhibit decreased activity compared to wild-type mice due to reduced duration of wake time
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• mice exhibit more frequent short and fewer long episodes of wake and non-rapid eye movement (NREM) sleep compared to wild-type mice
• mice exhibit more REM sleep than wild-type mice during the night and direct transition from wake to REM sleep (DREM) unlike wild-type mice
• mice exhibit shorter transition from NREM to REM and more episodes of REM at night than wild-type mice
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narcolepsy
(
J:141058
)
homeostasis/metabolism
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• body temperature is higher than in wild-type between ZT14 and ZT18 and lower between ZT22 and ZT4 likely due to larger sleep-state dependent fluctuations in body temperature compared to in wild-type mice
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• especially during the day
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growth/size/body
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• female but not male mice over 150 days in age have significant increases in body weight compared to littermate controls
• Background Sensitivity: the increase is not as great as found in mice with the same transgene on a mixed (C57BL/6 and DBA/1) background
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nervous system
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• mice exhibit a higher electroencephalogram power densities at the theta and beta band during DREM than in wild-type mice indicating a cataplexy-like state
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