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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plk4tm1Jwd
targeted mutation 1, James W Dennis
MGI:2387766
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plk4tm1Jwd/Plk4tm1Jwd either: 129 or (involves: 129S1/Sv * 129X1/SvJ * CD-1) MGI:3041282


Genotype
MGI:3041282
hm1
Allelic
Composition
Plk4tm1Jwd/Plk4tm1Jwd
Genetic
Background
either: 129 or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plk4tm1Jwd mutation (0 available); any Plk4 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cellular
• the cell cycle is arrested during mitosis
• increased apoptosis

embryo
• embryos arrest after gastrulation at E7.5
• smaller than normal at E8.5
• neural plate is present but no neural tube forms
• gastrulation occurred but no somite development

growth/size/body
• smaller than normal at E8.5

nervous system
• neural plate is present but no neural tube forms





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory