All Phenotypes Plk4<tm1Jwd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plk4^tm1Jwd
targeted mutation 1, James W Dennis
MGI:2387766

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plk4^tm1Jwd/Plk4^tm1Jwd	either: 129 or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3041282

Allelic Composition	Plk4^tm1Jwd/Plk4^tm1Jwd
Genetic Background	either: 129 or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plk4^tm1Jwd mutation (0 available); any Plk4 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• development arrested around E7.5

cellular

abnormal mitosis ( J:68142 )

• the cell cycle is arrested during mitosis

abnormal apoptosis ( J:68142 )

• increased apoptosis

embryo

embryonic growth arrest ( J:68142 )

• embryos arrest after gastrulation at E7.5

decreased embryo size ( J:68142 )

• smaller than normal at E8.5

abnormal neural tube morphology ( J:68142 )

• neural plate is present but no neural tube forms

absent somites ( J:68142 )

• gastrulation occurred but no somite development

growth/size/body

decreased embryo size ( J:68142 )

• smaller than normal at E8.5

nervous system

abnormal neural tube morphology ( J:68142 )

• neural plate is present but no neural tube forms

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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