mortality/aging
• development arrested around E7.5
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cellular
• the cell cycle is arrested during mitosis
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• increased apoptosis
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embryo
• embryos arrest after gastrulation at E7.5
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• smaller than normal at E8.5
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• neural plate is present but no neural tube forms
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• gastrulation occurred but no somite development
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growth/size/body
• smaller than normal at E8.5
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nervous system
• neural plate is present but no neural tube forms
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