All Phenotypes Tg(Thy1-Serpine2)2Dmn MGI Mouse

cellular

• following crush damage, Schwann cell proliferation is decreased

nervous system

abnormal sciatic nerve morphology ( J:121223 )

• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed

• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice

abnormal Schwann cell physiology ( J:121223 )

• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased

• following crush damage, Schwann cell proliferation is decreased

• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed

• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice

homeostasis/metabolism

abnormal response to injury ( J:121223 )

• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed

• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice

• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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