mortality/aging
• a small number of homozygotes die by 8 weeks of age
|
reproductive system
• seminal vesicles lack any sign of folding and are more darkly colored due to lack of secretions in the lumen
• however, testes, epididymis, vas deferens, and prostate are normal
|
• seminal vesicle precursors grown in organ culture exhibit very little epithelial branching compared to extensive branching in wild-type
|
• the epithelium of the finger-like projections of the seminal vesicles contains scattered large cells with large nuclei and multiple nucleoli
|
endocrine/exocrine glands
• seminal vesicles lack any sign of folding and are more darkly colored due to lack of secretions in the lumen
• however, testes, epididymis, vas deferens, and prostate are normal
|
• seminal vesicle precursors grown in organ culture exhibit very little epithelial branching compared to extensive branching in wild-type
|
• the epithelium of the finger-like projections of the seminal vesicles contains scattered large cells with large nuclei and multiple nucleoli
|
nervous system
hydrocephaly
(
J:69607
)
• the small number of mutants that die by 8 weeks of age show indications of hydrocephaly
|