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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gdf7tm1Kng
targeted mutation 1, David M Kingsley
MGI:2387817
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gdf7tm1Kng/Gdf7tm1Kng involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3722873


Genotype
MGI:3722873
hm1
Allelic
Composition
Gdf7tm1Kng/Gdf7tm1Kng
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf7tm1Kng mutation (1 available); any Gdf7 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a small number of homozygotes die by 8 weeks of age

reproductive system
• seminal vesicles lack any sign of folding and are more darkly colored due to lack of secretions in the lumen
• however, testes, epididymis, vas deferens, and prostate are normal
• seminal vesicle precursors grown in organ culture exhibit very little epithelial branching compared to extensive branching in wild-type
• the epithelium of the finger-like projections of the seminal vesicles contains scattered large cells with large nuclei and multiple nucleoli

endocrine/exocrine glands
• seminal vesicles lack any sign of folding and are more darkly colored due to lack of secretions in the lumen
• however, testes, epididymis, vas deferens, and prostate are normal
• seminal vesicle precursors grown in organ culture exhibit very little epithelial branching compared to extensive branching in wild-type
• the epithelium of the finger-like projections of the seminal vesicles contains scattered large cells with large nuclei and multiple nucleoli

nervous system
• the small number of mutants that die by 8 weeks of age show indications of hydrocephaly





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory