Phenotypes associated with this allele

• Allele Symbol: Tsix^tm2Jtl
• Allele Name: targeted mutation 2, Jeannie T Lee
• Allele ID: MGI:2387818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tsix^tm2Jtl/Tsix^+	involves: 129 * M. m. castaneus	MGI:3699222
ot2	Tsix^tm2Jtl/Y	involves: 129 * M. m. castaneus	MGI:3699221

Genotype
MGI:3699222

ht1

• Allelic Composition: Tsix^tm2Jtl/Tsix⁺
• Genetic Background: involves: 129 * M. m. castaneus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:57967 )

♀ • in culture, female embryoid bodies with the mutant allele undergo massive cell death from days 8-15; female-specific lethality is observed in culture

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:57967 )

♀ • mutants show defects random X chromosome inactivation

abnormal imprinting ( J:57967 )

♀ • mutants show defects in imprinted and random X chromosome inactivation

Genotype
MGI:3699221

ot2

• Allelic Composition: Tsix^tm2Jtl/Y
• Genetic Background: involves: 129 * M. m. castaneus

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:57967 )

♂ • mutants show defects in random X chromosome inactivation

abnormal imprinting ( J:57967 )

♂ • mutants show defects in imprinted inactivation