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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hdac9tm1Eno
targeted mutation 1, Eric N Olson
MGI:2387834
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hdac9tm1Eno/Hdac9tm1Eno involves: 129S1/Sv * 129X1/SvJ MGI:3622906
cx2
Hdac4tm1Eno/Hdac4+
Hdac5tm1Eno/Hdac5tm1Eno
Hdac9tm1Eno/Hdac9+
involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:4418139
cx3
Hdac5tm1Eno/Hdac5tm1Eno
Hdac9tm1Eno/Hdac9tm1Eno
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3056194
cx4
Hdac9tm1Eno/Hdac9tm1Eno
Tg(Myh6-Ppp3ca)37Eno/?
involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3622907


Genotype
MGI:3622906
hm1
Allelic
Composition
Hdac9tm1Eno/Hdac9tm1Eno
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac9tm1Eno mutation (0 available); any Hdac9 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• although not displaying any abnormalities at birth, cardiac hypertrophy is present at 8 months of age but not at 1 month
• 46% increase in heart weight/body weight ratio
• cardiac function remained normal through 8 months of age
• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls

muscle
N
• no change in the abundance of slow fibers
• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls

growth/size/body
• although not displaying any abnormalities at birth, cardiac hypertrophy is present at 8 months of age but not at 1 month
• 46% increase in heart weight/body weight ratio
• cardiac function remained normal through 8 months of age
• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls




Genotype
MGI:4418139
cx2
Allelic
Composition
Hdac4tm1Eno/Hdac4+
Hdac5tm1Eno/Hdac5tm1Eno
Hdac9tm1Eno/Hdac9+
Genetic
Background
involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4tm1Eno mutation (0 available); any Hdac4 mutation (112 available)
Hdac5tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Hdac9tm1Eno mutation (0 available); any Hdac9 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• increase in slow fibers




Genotype
MGI:3056194
cx3
Allelic
Composition
Hdac5tm1Eno/Hdac5tm1Eno
Hdac9tm1Eno/Hdac9tm1Eno
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Hdac9tm1Eno mutation (0 available); any Hdac9 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygous embryos begin to die around E15.5 with only about 12% of double homozygotes surviving to adulthood

cardiovascular system
• at E15.5 ventricular septal defects were seen in 77% of double homozygous embryos often associated with hemorrhages
• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated
• at E15.5 thin ventricular walls were seen in 20% of double homozygous embryos often associated with hemorrhages
• hemorrhages are seen throughout the body of some mutant embryos at E15.5

growth/size/body
• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated
• severe growth retardation is seen with surviving adults weighing 1/3 as much as wild-type mice

muscle
• soleus muscles show an increase in the percentage of slow myofibers




Genotype
MGI:3622907
cx4
Allelic
Composition
Hdac9tm1Eno/Hdac9tm1Eno
Tg(Myh6-Ppp3ca)37Eno/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac9tm1Eno mutation (0 available); any Hdac9 mutation (51 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cardiac hypertrophy due to hypertrophy of individual cardiomyocytes
• cardiac mass increases by 220% as opposed to 110% for controls

muscle
• cardiac hypertrophy due to hypertrophy of individual cardiomyocytes

growth/size/body
• cardiac mass increases by 220% as opposed to 110% for controls





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory