All Phenotypes Hdac9<tm1Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hdac9^tm1Eno
targeted mutation 1, Eric N Olson
MGI:2387834

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac9^tm1Eno/Hdac9^tm1Eno	involves: 129S1/Sv * 129X1/SvJ	MGI:3622906
cx2	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:4418139
cx3	Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9^tm1Eno	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3056194
cx4	Hdac9^tm1Eno/Hdac9^tm1Eno Tg(Myh6-Ppp3ca)37Eno/?	involves: 129S1/Sv * 129X1/SvJ * FVB	MGI:3622907

Allelic Composition	Hdac9^tm1Eno/Hdac9^tm1Eno
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:78734 )

• although not displaying any abnormalities at birth, cardiac hypertrophy is present at 8 months of age but not at 1 month

• 46% increase in heart weight/body weight ratio

• cardiac function remained normal through 8 months of age

heart left ventricle hypertrophy ( J:78734 )

• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls

muscle

muscle phenotype ( J:127416 )

N	• no change in the abundance of slow fibers

heart left ventricle hypertrophy ( J:78734 )

• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls

growth/size/body

cardiac hypertrophy ( J:78734 )

• although not displaying any abnormalities at birth, cardiac hypertrophy is present at 8 months of age but not at 1 month

• 46% increase in heart weight/body weight ratio

• cardiac function remained normal through 8 months of age

heart left ventricle hypertrophy ( J:78734 )

• mass increases by 105% as a result of thoracic aorta banding as opposed to 56% in controls

Allelic Composition	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺
Genetic Background	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (112 available)
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• increase in slow fibers

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9^tm1Eno
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:93021 )

• double homozygous embryos begin to die around E15.5 with only about 12% of double homozygotes surviving to adulthood

cardiovascular system

ventricular septal defect ( J:93021 )

• at E15.5 ventricular septal defects were seen in 77% of double homozygous embryos often associated with hemorrhages

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

thin ventricular wall ( J:93021 )

• at E15.5 thin ventricular walls were seen in 20% of double homozygous embryos often associated with hemorrhages

hemorrhage ( J:93021 )

• hemorrhages are seen throughout the body of some mutant embryos at E15.5

growth/size/body

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

postnatal growth retardation ( J:93021 )

• severe growth retardation is seen with surviving adults weighing 1/3 as much as wild-type mice

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• soleus muscles show an increase in the percentage of slow myofibers

Allelic Composition	Hdac9^tm1Eno/Hdac9^tm1Eno Tg(Myh6-Ppp3ca)37Eno/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (51 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:78734 )

• cardiac hypertrophy due to hypertrophy of individual cardiomyocytes

cardiac hypertrophy ( J:78734 )

• cardiac mass increases by 220% as opposed to 110% for controls

muscle

abnormal myocardium layer morphology ( J:78734 )

• cardiac hypertrophy due to hypertrophy of individual cardiomyocytes

growth/size/body

cardiac hypertrophy ( J:78734 )

• cardiac mass increases by 220% as opposed to 110% for controls

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