All Phenotypes Vav1<tm2Bbd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^tm2Bbd/Vav1^tm2Bbd	B6.129-Vav1^tm2Bbd	MGI:3841985
hm2	Vav1^tm2Bbd/Vav1^tm2Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3841811
hm3	Vav1^tm2Bbd/Vav1^tm2Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3841810
cx4	Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd	B6.129-Itk^tm1Litt Vav1^tm2Bbd	MGI:3841989
cx5	Vav1^tm2Bbd/Vav1^tm2Bbd Vav2^tm1Kdf/Vav2^tm1Kdf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3841948

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	B6.129-Vav1^tm2Bbd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:71161 )

N	• no decrease is detected in the number of NK cells in the thymus, bone marrow, spleen, and liver

abnormal CD4-positive T cell differentiation ( J:141390 )

• only about 50% of CD4+ cells have a mature phenotype

abnormal positive T cell selection ( J:141390 )

• TCR dependent Ca2+ mobilization is reduced

decreased T cell number ( J:141390 )

• decrease in the number of peripheral T cells

decreased double-positive T cell number ( J:141390 )

• overall decrease in the number of double negative cells with a relative increase in the number of DN3 cells

decreased NK T cell number ( J:71161 )

• decrease in the number of NK T cells in the thymus, bone marrow, spleen, and liver

impaired natural killer cell mediated cytotoxicity ( J:71161 )

• ability to spontaneously lyse YAC1 cells is impaired in freshly isolated NK cells

• ability to spontaneously lyse EL4, C4.4.25, RMA, and RMA/S cells is impaired in lymphokine activated killer cells

• however, addition of anti-Thy 1.2 antibodies increases cytotoxicity against RMA cells to the same degree as in wild-type cells

• however, lymphokine activated killer cells are able to lyse YAC1 cells

abnormal T cell physiology ( J:141390 )

• modest reduction in double positive T cell half-life

decreased interleukin-4 secretion ( J:71161 )

• about a 90% reduction in IL4 secretion by splenocytes following anti-CD3 antibody stimulation

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:141390 )

• only about 50% of CD4+ cells have a mature phenotype

abnormal positive T cell selection ( J:141390 )

• TCR dependent Ca2+ mobilization is reduced

decreased T cell number ( J:141390 )

• decrease in the number of peripheral T cells

decreased double-positive T cell number ( J:141390 )

• overall decrease in the number of double negative cells with a relative increase in the number of DN3 cells

decreased NK T cell number ( J:71161 )

• decrease in the number of NK T cells in the thymus, bone marrow, spleen, and liver

impaired natural killer cell mediated cytotoxicity ( J:71161 )

• ability to spontaneously lyse YAC1 cells is impaired in freshly isolated NK cells

• ability to spontaneously lyse EL4, C4.4.25, RMA, and RMA/S cells is impaired in lymphokine activated killer cells

• however, addition of anti-Thy 1.2 antibodies increases cytotoxicity against RMA cells to the same degree as in wild-type cells

• however, lymphokine activated killer cells are able to lyse YAC1 cells

abnormal T cell physiology ( J:141390 )

• modest reduction in double positive T cell half-life

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

increased double-negative T cell number ( J:47596 )

• Background Sensitivity: unlike in mice on a CD-1 background where no differences in the numbers double negative precursors are detected, mice on a C57BL/6 background have an increase in the number of CD44-CD25+ precursor cells

abnormal B cell number ( J:55647 )

increased transitional stage B cell number ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo splenic cells is about 1:1 unlike in wild-type mice where this ratio is about 1:3

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is also about 1:1 in the lymph nodes

decreased B-1 B cell number ( J:55647 )

• 50 - 75% reduction in the number of CD5+ B1 B cells in the peritoneal cavity

abnormal T cell number ( J:47596 )

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal splenic cell ratio ( J:69806 )

decreased IgG level ( J:55647 )

• decreased T cell dependent IgG response to VSV infection

decreased IgG1 level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG2a level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG3 level ( J:69806 )

• following TNP-Ficoll stimulation

abnormal lymph node cell ratio ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is about 1:1

abnormal response to infection ( J:55647 )

hematopoietic system

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

abnormal B cell number ( J:55647 )

increased transitional stage B cell number ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo splenic cells is about 1:1 unlike in wild-type mice where this ratio is about 1:3

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is also about 1:1 in the lymph nodes

decreased B-1 B cell number ( J:55647 )

• 50 - 75% reduction in the number of CD5+ B1 B cells in the peritoneal cavity

abnormal T cell number ( J:47596 )

increased double-negative T cell number ( J:47596 )

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal splenic cell ratio ( J:69806 )

decreased IgG level ( J:55647 )

• decreased T cell dependent IgG response to VSV infection

decreased IgG1 level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG2a level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG3 level ( J:69806 )

• following TNP-Ficoll stimulation

cellular

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:47596 )

N	• Background Sensitivity: unlike in mice on a C57BL/6 background, no change in the number of double negative precursor cells is detected in mice on a CD-1 background

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B-1 B cell number ( J:47596 )

• in the peritoneal cavity

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal T cell activation ( J:47596 )

• T cells are blocked in the G1 phase of the cell cycle but do not undergo enhanced apoptosis after TCR activation

• T cells display a severe defect in antigen stimulated actin polymerization

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

decreased interleukin-2 secretion ( J:47596 )

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase production of IL2 over that induced by stimulation with anti-CD3 antibody alone

hematopoietic system

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B-1 B cell number ( J:47596 )

• in the peritoneal cavity

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal T cell activation ( J:47596 )

• T cells are blocked in the G1 phase of the cell cycle but do not undergo enhanced apoptosis after TCR activation

• T cells display a severe defect in antigen stimulated actin polymerization

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

endocrine/exocrine glands

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

cellular

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

Allelic Composition	Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	B6.129-Itk^tm1Litt Vav1^tm2Bbd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itk^tm1Litt mutation (2 available); any Itk mutation (50 available)
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:141390 )

• slight but significant increase in the number of B cells compared to wild-type mice

abnormal T cell morphology ( J:141390 )

• most remaining single positive T cells have an activated/memory like phenotype

abnormal CD4-positive T cell differentiation ( J:141390 )

• virtually no CD4+ cells have a mature phenotype

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141390 )

• lack of cells with a CD3^hi phenotype

abnormal positive T cell selection ( J:141390 )

• the CD69+ subset is almost completely absent and TCR dependent Ca2+ mobilization is nearly abolished

decreased T cell number ( J:141390 )

• dramatic loss of peripheral T cells

• lymph node T cell numbers are about 4 fold lower compared to mice homozygous null for Vav1 alone

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

decreased double-positive T cell number ( J:141390 )

• compared to wild-type mice and mice homozygous for either allele alone

• relative increase in the DN3 subset is similar to mice homozygous null for Vav1 alone

decreased CD4-positive, alpha-beta T cell number ( J:141390 )

decreased CD8-positive, alpha-beta T cell number ( J:141390 )

abnormal T cell physiology ( J:141390 )

• dramatic reduction in double positive T cell half-life compared to wild-type cells

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

hematopoietic system

increased B cell number ( J:141390 )

• slight but significant increase in the number of B cells compared to wild-type mice

abnormal T cell morphology ( J:141390 )

• most remaining single positive T cells have an activated/memory like phenotype

abnormal CD4-positive T cell differentiation ( J:141390 )

• virtually no CD4+ cells have a mature phenotype

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141390 )

• lack of cells with a CD3^hi phenotype

abnormal positive T cell selection ( J:141390 )

• the CD69+ subset is almost completely absent and TCR dependent Ca2+ mobilization is nearly abolished

decreased T cell number ( J:141390 )

• dramatic loss of peripheral T cells

• lymph node T cell numbers are about 4 fold lower compared to mice homozygous null for Vav1 alone

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

decreased double-positive T cell number ( J:141390 )

• compared to wild-type mice and mice homozygous for either allele alone

• relative increase in the DN3 subset is similar to mice homozygous null for Vav1 alone

decreased CD4-positive, alpha-beta T cell number ( J:141390 )

decreased CD8-positive, alpha-beta T cell number ( J:141390 )

abnormal T cell physiology ( J:141390 )

• dramatic reduction in double positive T cell half-life compared to wild-type cells

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

cellular

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

endocrine/exocrine glands

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd Vav2^tm1Kdf/Vav2^tm1Kdf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)
Vav2^tm1Kdf mutation (1 available); any Vav2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

abnormal B cell differentiation ( J:69806 )

• partial block in B cell differentiation

abnormal T cell differentiation ( J:69806 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B cell number ( J:69806 )

• about an 80% reduction in the number of B cells in the spleen

decreased mature B cell number ( J:69806 )

• marked decrease in the number of B220^hiIgM^lo B cells in the bone marrow

• this decrease is more severe than in mice homozygous null for Vav2 alone

• pronounced decrease in the number of mature B cells in the spleen

decreased B-1 B cell number ( J:69806 )

• in the peritoneal cavity

decreased T cell number ( J:69806 )

• splenic and lymph node T cell populations are reduced by about 90% and 50% compared to wild-type controls and mice homozygous null for Vav1 alone, respectively

decreased CD8-positive, alpha-beta T cell number ( J:69806 )

• decreased compared to wild-type controls and mice homozygous null for Vav1 alone

abnormal splenic cell ratio ( J:69806 )

• relative increase in the number of immature B cells compared to mature B cells

abnormal B cell activation ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

decreased immunoglobulin level ( J:69806 )

decreased IgG1 level ( J:69806 )

• basal levels of IgG1 are reduced

decreased IgG2b level ( J:69806 )

• basal levels of IgG2b are reduced

decreased IgG3 level ( J:69806 )

• virtually no IgG3 is produced following TNP-Ficoll stimulation

• basal levels of IgG3 are reduced

decreased IgM level ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

• basal levels of IgM are reduced

abnormal lymph node cell ratio ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^hi is about 1:0.7

hematopoietic system

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

abnormal B cell differentiation ( J:69806 )

• partial block in B cell differentiation

abnormal T cell differentiation ( J:69806 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B cell number ( J:69806 )

• about an 80% reduction in the number of B cells in the spleen

decreased mature B cell number ( J:69806 )

• marked decrease in the number of B220^hiIgM^lo B cells in the bone marrow

• this decrease is more severe than in mice homozygous null for Vav2 alone

• pronounced decrease in the number of mature B cells in the spleen

decreased B-1 B cell number ( J:69806 )

• in the peritoneal cavity

decreased T cell number ( J:69806 )

• splenic and lymph node T cell populations are reduced by about 90% and 50% compared to wild-type controls and mice homozygous null for Vav1 alone, respectively

decreased CD8-positive, alpha-beta T cell number ( J:69806 )

• decreased compared to wild-type controls and mice homozygous null for Vav1 alone

abnormal splenic cell ratio ( J:69806 )

• relative increase in the number of immature B cells compared to mature B cells

abnormal B cell activation ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

decreased immunoglobulin level ( J:69806 )

decreased IgG1 level ( J:69806 )

• basal levels of IgG1 are reduced

decreased IgG2b level ( J:69806 )

• basal levels of IgG2b are reduced

decreased IgG3 level ( J:69806 )

• virtually no IgG3 is produced following TNP-Ficoll stimulation

• basal levels of IgG3 are reduced

decreased IgM level ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

• basal levels of IgM are reduced

endocrine/exocrine glands

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

cellular

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24