All Phenotypes Vav1<tm2Bbd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^tm2Bbd/Vav1^tm2Bbd	B6.129-Vav1^tm2Bbd	MGI:3841985
hm2	Vav1^tm2Bbd/Vav1^tm2Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3841811
hm3	Vav1^tm2Bbd/Vav1^tm2Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3841810
cx4	Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd	B6.129-Itk^tm1Litt Vav1^tm2Bbd	MGI:3841989
cx5	Vav1^tm2Bbd/Vav1^tm2Bbd Vav2^tm1Kdf/Vav2^tm1Kdf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3841948

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	B6.129-Vav1^tm2Bbd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:71161 )

N	• no decrease is detected in the number of NK cells in the thymus, bone marrow, spleen, and liver

abnormal CD4-positive T cell differentiation ( J:141390 )

• only about 50% of CD4+ cells have a mature phenotype

abnormal positive T cell selection ( J:141390 )

• TCR dependent Ca2+ mobilization is reduced

decreased T cell number ( J:141390 )

• decrease in the number of peripheral T cells

decreased double-positive T cell number ( J:141390 )

• overall decrease in the number of double negative cells with a relative increase in the number of DN3 cells

decreased NK T cell number ( J:71161 )

• decrease in the number of NK T cells in the thymus, bone marrow, spleen, and liver

impaired natural killer cell mediated cytotoxicity ( J:71161 )

• ability to spontaneously lyse YAC1 cells is impaired in freshly isolated NK cells

• ability to spontaneously lyse EL4, C4.4.25, RMA, and RMA/S cells is impaired in lymphokine activated killer cells

• however, addition of anti-Thy 1.2 antibodies increases cytotoxicity against RMA cells to the same degree as in wild-type cells

• however, lymphokine activated killer cells are able to lyse YAC1 cells

abnormal T cell physiology ( J:141390 )

• modest reduction in double positive T cell half-life

decreased interleukin-4 secretion ( J:71161 )

• about a 90% reduction in IL4 secretion by splenocytes following anti-CD3 antibody stimulation

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:141390 )

• only about 50% of CD4+ cells have a mature phenotype

abnormal positive T cell selection ( J:141390 )

• TCR dependent Ca2+ mobilization is reduced

decreased T cell number ( J:141390 )

• decrease in the number of peripheral T cells

decreased double-positive T cell number ( J:141390 )

• overall decrease in the number of double negative cells with a relative increase in the number of DN3 cells

decreased NK T cell number ( J:71161 )

• decrease in the number of NK T cells in the thymus, bone marrow, spleen, and liver

impaired natural killer cell mediated cytotoxicity ( J:71161 )

• ability to spontaneously lyse YAC1 cells is impaired in freshly isolated NK cells

• ability to spontaneously lyse EL4, C4.4.25, RMA, and RMA/S cells is impaired in lymphokine activated killer cells

• however, addition of anti-Thy 1.2 antibodies increases cytotoxicity against RMA cells to the same degree as in wild-type cells

• however, lymphokine activated killer cells are able to lyse YAC1 cells

abnormal T cell physiology ( J:141390 )

• modest reduction in double positive T cell half-life

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

increased double-negative T cell number ( J:47596 )

• Background Sensitivity: unlike in mice on a CD-1 background where no differences in the numbers double negative precursors are detected, mice on a C57BL/6 background have an increase in the number of CD44-CD25+ precursor cells

abnormal B cell number ( J:55647 )

increased transitional stage B cell number ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo splenic cells is about 1:1 unlike in wild-type mice where this ratio is about 1:3

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is also about 1:1 in the lymph nodes

decreased B-1 B cell number ( J:55647 )

• 50 - 75% reduction in the number of CD5+ B1 B cells in the peritoneal cavity

abnormal T cell number ( J:47596 )

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal splenic cell ratio ( J:69806 )

decreased IgG level ( J:55647 )

• decreased T cell dependent IgG response to VSV infection

decreased IgG1 level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG2a level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG3 level ( J:69806 )

• following TNP-Ficoll stimulation

abnormal lymph node cell ratio ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is about 1:1

abnormal response to infection ( J:55647 )

hematopoietic system

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

abnormal B cell number ( J:55647 )

increased transitional stage B cell number ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo splenic cells is about 1:1 unlike in wild-type mice where this ratio is about 1:3

• the ratio of IgM^hiIgD^hi to IgM^loIgD^lo is also about 1:1 in the lymph nodes

decreased B-1 B cell number ( J:55647 )

• 50 - 75% reduction in the number of CD5+ B1 B cells in the peritoneal cavity

abnormal T cell number ( J:47596 )

increased double-negative T cell number ( J:47596 )

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal splenic cell ratio ( J:69806 )

decreased IgG level ( J:55647 )

• decreased T cell dependent IgG response to VSV infection

decreased IgG1 level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG2a level ( J:55647 )

• following immunization with the T cell dependent hapten NIP conjugated to OVA

decreased IgG3 level ( J:69806 )

• following TNP-Ficoll stimulation

cellular

decreased B cell proliferation ( J:55647 , J:69806 )

• in response to a polyclonal or monoclonal anti-IgM antibody stimulation (J:55647)

• increasing the concentration of the polyclonal antibody can partially restore proliferation (J:55647)

• however, proliferation in response to LPS, IL4 or anti-CD23 antibody stimulation is normal (J:55647)

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background (J:69806)

• proliferation in response to stimulation with a stronger antigen (polyclonal anti-IgM antibody) is about 50% of control proliferation (J:69806)

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:47596 )

N	• Background Sensitivity: unlike in mice on a C57BL/6 background, no change in the number of double negative precursor cells is detected in mice on a CD-1 background

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B-1 B cell number ( J:47596 )

• in the peritoneal cavity

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal T cell activation ( J:47596 )

• T cells are blocked in the G1 phase of the cell cycle but do not undergo enhanced apoptosis after TCR activation

• T cells display a severe defect in antigen stimulated actin polymerization

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

decreased interleukin-2 secretion ( J:47596 )

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase production of IL2 over that induced by stimulation with anti-CD3 antibody alone

hematopoietic system

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

abnormal T cell differentiation ( J:47596 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B-1 B cell number ( J:47596 )

• in the peritoneal cavity

decreased CD4-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD4+ T cells in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:47596 )

• decrease in the total and relative frequency of CD8+ T cells in the thymus and periphery

abnormal T cell activation ( J:47596 )

• T cells are blocked in the G1 phase of the cell cycle but do not undergo enhanced apoptosis after TCR activation

• T cells display a severe defect in antigen stimulated actin polymerization

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

endocrine/exocrine glands

thymus hypoplasia ( J:47596 )

• slightly reduced thymic cellularity

cellular

decreased T cell proliferation ( J:47596 )

• decreased proliferation following stimulation with an anti-CD3E antibody that is partially overcome by addition of IL2

• costimulation with anti-CD3 and anti-CD28 antibodies does not increase proliferation over that induced by stimulation with anti-CD3 antibody alone

Allelic Composition	Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd
Genetic Background	B6.129-Itk^tm1Litt Vav1^tm2Bbd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itk^tm1Litt mutation (2 available); any Itk mutation (50 available)
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:141390 )

• slight but significant increase in the number of B cells compared to wild-type mice

abnormal T cell morphology ( J:141390 )

• most remaining single positive T cells have an activated/memory like phenotype

abnormal CD4-positive T cell differentiation ( J:141390 )

• virtually no CD4+ cells have a mature phenotype

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141390 )

• lack of cells with a CD3^hi phenotype

abnormal positive T cell selection ( J:141390 )

• the CD69+ subset is almost completely absent and TCR dependent Ca2+ mobilization is nearly abolished

decreased T cell number ( J:141390 )

• dramatic loss of peripheral T cells

• lymph node T cell numbers are about 4 fold lower compared to mice homozygous null for Vav1 alone

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

decreased double-positive T cell number ( J:141390 )

• compared to wild-type mice and mice homozygous for either allele alone

• relative increase in the DN3 subset is similar to mice homozygous null for Vav1 alone

decreased CD4-positive, alpha-beta T cell number ( J:141390 )

decreased CD8-positive, alpha-beta T cell number ( J:141390 )

abnormal T cell physiology ( J:141390 )

• dramatic reduction in double positive T cell half-life compared to wild-type cells

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

hematopoietic system

increased B cell number ( J:141390 )

• slight but significant increase in the number of B cells compared to wild-type mice

abnormal T cell morphology ( J:141390 )

• most remaining single positive T cells have an activated/memory like phenotype

abnormal CD4-positive T cell differentiation ( J:141390 )

• virtually no CD4+ cells have a mature phenotype

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141390 )

• lack of cells with a CD3^hi phenotype

abnormal positive T cell selection ( J:141390 )

• the CD69+ subset is almost completely absent and TCR dependent Ca2+ mobilization is nearly abolished

decreased T cell number ( J:141390 )

• dramatic loss of peripheral T cells

• lymph node T cell numbers are about 4 fold lower compared to mice homozygous null for Vav1 alone

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

decreased double-positive T cell number ( J:141390 )

• compared to wild-type mice and mice homozygous for either allele alone

• relative increase in the DN3 subset is similar to mice homozygous null for Vav1 alone

decreased CD4-positive, alpha-beta T cell number ( J:141390 )

decreased CD8-positive, alpha-beta T cell number ( J:141390 )

abnormal T cell physiology ( J:141390 )

• dramatic reduction in double positive T cell half-life compared to wild-type cells

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

cellular

increased T cell apoptosis ( J:141390 )

• compared to wild-type mice or mice homozygous for either allele alone

• increase in early apoptotic cells in the double positive cell population

endocrine/exocrine glands

decreased thymocyte number ( J:141390 )

• compared to mice homozygous null for Vav1 alone

Allelic Composition	Vav1^tm2Bbd/Vav1^tm2Bbd Vav2^tm1Kdf/Vav2^tm1Kdf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Bbd mutation (1 available); any Vav1 mutation (60 available)
Vav2^tm1Kdf mutation (1 available); any Vav2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

abnormal B cell differentiation ( J:69806 )

• partial block in B cell differentiation

abnormal T cell differentiation ( J:69806 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B cell number ( J:69806 )

• about an 80% reduction in the number of B cells in the spleen

decreased mature B cell number ( J:69806 )

• marked decrease in the number of B220^hiIgM^lo B cells in the bone marrow

• this decrease is more severe than in mice homozygous null for Vav2 alone

• pronounced decrease in the number of mature B cells in the spleen

decreased B-1 B cell number ( J:69806 )

• in the peritoneal cavity

decreased T cell number ( J:69806 )

• splenic and lymph node T cell populations are reduced by about 90% and 50% compared to wild-type controls and mice homozygous null for Vav1 alone, respectively

decreased CD8-positive, alpha-beta T cell number ( J:69806 )

• decreased compared to wild-type controls and mice homozygous null for Vav1 alone

abnormal splenic cell ratio ( J:69806 )

• relative increase in the number of immature B cells compared to mature B cells

abnormal B cell activation ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

decreased immunoglobulin level ( J:69806 )

decreased IgG1 level ( J:69806 )

• basal levels of IgG1 are reduced

decreased IgG2b level ( J:69806 )

• basal levels of IgG2b are reduced

decreased IgG3 level ( J:69806 )

• virtually no IgG3 is produced following TNP-Ficoll stimulation

• basal levels of IgG3 are reduced

decreased IgM level ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

• basal levels of IgM are reduced

abnormal lymph node cell ratio ( J:69806 )

• the ratio of IgM^hiIgD^hi to IgM^loIgD^hi is about 1:0.7

hematopoietic system

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

abnormal B cell differentiation ( J:69806 )

• partial block in B cell differentiation

abnormal T cell differentiation ( J:69806 )

• partial block in differentiation of double positive T cells into single positive T cells

decreased B cell number ( J:69806 )

• about an 80% reduction in the number of B cells in the spleen

decreased mature B cell number ( J:69806 )

• marked decrease in the number of B220^hiIgM^lo B cells in the bone marrow

• this decrease is more severe than in mice homozygous null for Vav2 alone

• pronounced decrease in the number of mature B cells in the spleen

decreased B-1 B cell number ( J:69806 )

• in the peritoneal cavity

decreased T cell number ( J:69806 )

• splenic and lymph node T cell populations are reduced by about 90% and 50% compared to wild-type controls and mice homozygous null for Vav1 alone, respectively

decreased CD8-positive, alpha-beta T cell number ( J:69806 )

• decreased compared to wild-type controls and mice homozygous null for Vav1 alone

abnormal splenic cell ratio ( J:69806 )

• relative increase in the number of immature B cells compared to mature B cells

abnormal B cell activation ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

decreased immunoglobulin level ( J:69806 )

decreased IgG1 level ( J:69806 )

• basal levels of IgG1 are reduced

decreased IgG2b level ( J:69806 )

• basal levels of IgG2b are reduced

decreased IgG3 level ( J:69806 )

• virtually no IgG3 is produced following TNP-Ficoll stimulation

• basal levels of IgG3 are reduced

decreased IgM level ( J:69806 )

• fail to produce IgM following TNP-Ficoll stimulation

• basal levels of IgM are reduced

endocrine/exocrine glands

thymus hypoplasia ( J:69806 )

• reduced by about 80% compared to controls

cellular

decreased B cell proliferation ( J:69806 )

• proliferation in response to stimulation with a weak antigen (monoclonal antibody to IgM, B7.6) barely exceeds background

• B cells are also virtually insensitive to stimulation with a stronger antigen (polyclonal anti-IgM antibody)

• cells fail to proliferate in response to LPS stimulation

• proliferation defect is seen in both mature and immature B cells

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