All Phenotypes Rad50<tm1Jpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rad50^tm1Jpt
targeted mutation 1, John H J Petrini
MGI:2387852

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad50^tm1Jpt/Rad50^tm1Jpt	involves: 129S7/SvEvBrd	MGI:3615763
ht2	Rad50^tm1Jpt/Rad50^tm4.1Jpt	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:5614074
ht3	Rad50^tm1Jpt/Rad50^tm2Jpt	involves: 129S7/SvEvBrd * C57BL/6	MGI:3615661
cn4	Rad50^tm1Jpt/Rad50^tm3Jpt Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129/Sv * C57BL/6	MGI:5614076
cn5	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Pcp2-cre)2Mpin/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:3832543
cn6	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Mx1-cre)1Cgn/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3832542

Allelic Composition	Rad50^tm1Jpt/Rad50^tm1Jpt
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Development of Rad50^tm1Jpt/Rad50^tm1Jpt embryos

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:56083 )

• embryos become abnormal by E6 and are largely resorbed by E7.5 and E8.5

growth/size/body

decreased embryo size ( J:56083 )

• some embryos between E6 and E8.5 are significantly smaller than wild-type, however no morphological abnormalities are seen at E5.5

embryo

abnormal developmental patterning ( J:56083 )

• in the small E6 embryos, endodermal and ectodermal cells are packed loosely and appear not to form the normal columnar ectoderm

embryonic growth arrest ( J:56083 )

• some E6.5 embryos have recognizable embryonic tissues but they are not developed appreciably and resemble E6 embryos both in size and degree of germ-layer differentiation

decreased embryo size ( J:56083 )

• some embryos between E6 and E8.5 are significantly smaller than wild-type, however no morphological abnormalities are seen at E5.5

cellular

increased cellular sensitivity to gamma-irradiation ( J:56083 )

• blastocyst explants exhibit increased sensitivity to gamma-irradiation, with only the nonmitotic trophoblast giant cells remaining viable after irradiation

decreased cell proliferation ( J:56083 )

• E6.5 embryos exhibit a decrease in the number of proliferating cells but no differences in the levels of apoptosis

Allelic Composition	Rad50^tm1Jpt/Rad50^tm4.1Jpt
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:209141 )

• no live mice are found at birth

Allelic Composition	Rad50^tm1Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 42% die by 5 months of age, however survival is increased compared to homozygous Rad50^tm2Jpt mice

hematopoietic system

anemia ( J:103922 )

• 12 of 29 die with anemia

abnormal hematopoietic system physiology ( J:103922 )

• most die from hematopoietic failure

neoplasm

increased lymphoma incidence ( J:103922 )

• 3 of 29 die with lymphoma

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:209141 )

• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system

abnormal intestine morphology ( J:209141 )

• intestinal defects are seen by day 9 of tamoxifen treatment

• die of intestinal failure

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:144766 )

• minor

nervous system

nervous system phenotype ( J:144766 )

N	• mice exhibit normal nervous system morphology with no increase in DNA damage

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide

abnormal hepatocyte morphology ( J:144766 )

• while liver regeneration following partial hepatectomy is normal, pIpC-treated hepatocytes exhibit an increase in DNA damage compared to wild-type cells

• however, a subset of hepatocytes resolve their DNA damage and divide

liver hypoplasia ( J:144766 )

• following partial hepatectomy, pIpC-treated livers exhibit reduced cellularity and endoreduplication compared to in similarly-treated wild-type mice

hematopoietic system

decreased bone marrow cell number ( J:144766 )

• the only viable bone marrow left after treatment with pIpC fails to exhibit recombination

cellular

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide

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