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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad50tm2Jpt
targeted mutation 2, John H J Petrini
MGI:2387857
Summary 17 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad50tm2Jpt/Rad50tm2Jpt either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:2450430
hm2
 		Rad50tm2Jpt/Rad50tm2Jpt involves: 129S7/SvEvBrd MGI:3771146
hm3
 		Rad50tm2Jpt/Rad50tm2Jpt involves: 129S7/SvEvBrd * C57BL/6 MGI:3615670
ht4
 		Rad50tm1Jpt/Rad50tm2Jpt involves: 129S7/SvEvBrd * C57BL/6 MGI:3615661
cx5
 		Chek2tm1Mak/Chek2tm1Mak
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3615684
cx6
 		Chek2tm1Mak/Chek2+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3615685
cx7
 		Rad50tm2Jpt/Rad50tm2Jpt
Smc1atm1Mbk/Smc1atm1Mbk 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3615687
cx8
 		Rad50tm2Jpt/Rad50tm2Jpt
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:2450431
cx9
 		Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615669
cx10
 		Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615663
cx11
 		Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * 129/Sv MGI:3771145
cx12
 		Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * 129/Sv MGI:3771144
cx13
 		Nbntm1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3615682
cx14
 		Nbntm1Jpt/Nbntm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3615681
cx15
 		Mre11atm1Jpt/Mre11a+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3615680
cx16
 		Mre11atm1Jpt/Mre11atm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3615671
cx17
 		Rad50tm2Jpt/Rad50tm2Jpt
Tg(BCL2)22Wehi/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:3615683


Genotype
MGI:2450430
hm1
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:78820 )
• mean age of death is 2.6 months +/- 1.8 months

neoplasm
increased T cell derived lymphoma incidence ( J:78820 )
• 20% of animals displayed metastatic thymic lymphomas at 4-7 months of age
increased leukemia incidence ( J:78820 )
• 1 animal displayed myeloid leukemia

growth/size/body
decreased body weight ( J:78820 )
• weight of mutant mice was 60% of controls
spleen hyperplasia ( J:78820 )
• 4 animals displayed splenic hyperplasia

hematopoietic system
abnormal thymus morphology ( J:78820 )
• abnormal thymus architecture
increased T cell derived lymphoma incidence ( J:78820 )
• 20% of animals displayed metastatic thymic lymphomas at 4-7 months of age
increased late pro-B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 2-3 fold increase in pro B cells
anemia ( J:78820 )
• by 4-8 weeks of age animals displayed gray and wasted appearance
impaired hematopoiesis ( J:78820 )
• at 4 weeks of age mutant mice displayed severe depletion of lymphocytes, macrophages, red blood cells, and platelets
absent bone marrow cell ( J:78820 )
• bone marrow devoid of hematopoietic cells and composed largely of adipocytes
decreased B cell number ( J:78820 )
• splenic B cell count at 4.8%-12% of wild-type
decreased immature B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 1.5-3 fold reduction in immature B cell population
decreased pre-B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 1.5-3 fold reduction in pre B cell population
decreased T cell number ( J:78820 )
• splenic T cell count at 7%-49% of wild-type
increased macrophage cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 2-3 fold increase in macrophages
abnormal spleen morphology ( J:78820 )
• abnormal spleen architecture
spleen hyperplasia ( J:78820 )
• 4 animals displayed splenic hyperplasia

immune system
increased late pro-B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 2-3 fold increase in pro B cells
decreased B cell number ( J:78820 )
• splenic B cell count at 4.8%-12% of wild-type
decreased immature B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 1.5-3 fold reduction in immature B cell population
decreased pre-B cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 1.5-3 fold reduction in pre B cell population
decreased T cell number ( J:78820 )
• splenic T cell count at 7%-49% of wild-type
increased macrophage cell number ( J:78820 )
• at 1 week of age mutant mice displayed a 2-3 fold increase in macrophages
abnormal thymus morphology ( J:78820 )
• abnormal thymus architecture
increased T cell derived lymphoma incidence ( J:78820 )
• 20% of animals displayed metastatic thymic lymphomas at 4-7 months of age
abnormal spleen morphology ( J:78820 )
• abnormal spleen architecture
spleen hyperplasia ( J:78820 )
• 4 animals displayed splenic hyperplasia

endocrine/exocrine glands
abnormal thymus morphology ( J:78820 )
• abnormal thymus architecture
increased T cell derived lymphoma incidence ( J:78820 )
• 20% of animals displayed metastatic thymic lymphomas at 4-7 months of age




Genotype
MGI:3771146
hm2
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:129762 )
• 97.5% of mice succumb to anemia at 8 months

hematopoietic system




Genotype
MGI:3615670
hm3
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• most die during the first 5 months of age

hematopoietic system
decreased pro-B cell number ( J:103922 )
• decrease in pro-B cell numbers
anemia ( J:103922 )
• 82 of 83 die with anemia
abnormal bone marrow cell morphology/development ( J:103922 )
• increase in apoptosis in the bone marrow as indicated by increased levels of cleaved Caspase-3
pancytopenia ( J:103922 )
• peripheral blood cell numbers are decreased (32% vs. 41% in wild-type)

immune system
decreased pro-B cell number ( J:103922 )
• decrease in pro-B cell numbers

neoplasm
increased lymphoma incidence ( J:103922 )
• 1 of 83 die with lymphoma




Genotype
MGI:3615661
ht4
Allelic
Composition		 Rad50tm1Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• 42% die by 5 months of age, however survival is increased compared to homozygous Rad50tm2Jpt mice

hematopoietic system
anemia ( J:103922 )
• 12 of 29 die with anemia
abnormal hematopoietic system physiology ( J:103922 )
• most die from hematopoietic failure

neoplasm
increased lymphoma incidence ( J:103922 )
• 3 of 29 die with lymphoma




Genotype
MGI:3615684
cx5
Allelic
Composition		 Chek2tm1Mak/Chek2tm1Mak
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2tm1Mak mutation (1 available); any Chek2 mutation (54 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• 13 of 65 die by 5 months of age, however survival time is increased compared to homozygous Rad50tm2Jpt mice, as 52 mutants survive past 5 months of age and none develop anemia

neoplasm
increased lymphoma incidence ( J:103922 )
• 10 of 65 mice develop lymphoma

hematopoietic system
hematopoietic system phenotype ( J:103922 )
N
• exhibit hematopoietic rescue of the abnormalities seen in homozygous Rad50tm2Jpt mice, with numbers of double-negative T cells, pro-B cells, and macrophages within 2-fold levels of wild-type levels




Genotype
MGI:3615685
cx6
Allelic
Composition		 Chek2tm1Mak/Chek2+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2tm1Mak mutation (1 available); any Chek2 mutation (54 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• 31 of 41 die by 5 months of age

hematopoietic system
abnormal pro-B cell morphology ( J:103922 )
• pro-B cell numbers are similar to that in homozygous Rad50tm2Jpt mice
decreased double-negative T cell number ( J:103922 )
• double-negative T cell numbers are similar to that in homozygous Rad50tm2Jpt mice
anemia ( J:103922 )
• 36 of 41 develop anemia
decreased macrophage cell number ( J:103922 )
• macrophage numbers are similar to that in homozygous Rad50tm2Jpt mice

immune system
abnormal pro-B cell morphology ( J:103922 )
• pro-B cell numbers are similar to that in homozygous Rad50tm2Jpt mice
decreased double-negative T cell number ( J:103922 )
• double-negative T cell numbers are similar to that in homozygous Rad50tm2Jpt mice
decreased macrophage cell number ( J:103922 )
• macrophage numbers are similar to that in homozygous Rad50tm2Jpt mice




Genotype
MGI:3615687
cx7
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Smc1atm1Mbk/Smc1atm1Mbk
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
Smc1atm1Mbk mutation (1 available); any Smc1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• double homozygotes are indistinguishable from homozygous Rad50tm2Jpt mice with respect to survival and die within 5 months after birth

hematopoietic system
abnormal hematopoietic system morphology/development ( J:103922 )
• double homozygotes are indistinguishable from homozygous Rad50 mice with respect to hematopoietic cell numbers
abnormal pro-B cell morphology ( J:103922 )
• pro-B cell numbers are similar to that in homozygous Rad50 mice
decreased double-negative T cell number ( J:103922 )
• double-negative T cell numbers are similar to that in homozygous Rad50 mice
anemia ( J:103922 )
• 26 of 27 develop anemia
decreased macrophage cell number ( J:103922 )
• macrophage numbers are similar to that in homozygous Rad50 mice

immune system
abnormal pro-B cell morphology ( J:103922 )
• pro-B cell numbers are similar to that in homozygous Rad50 mice
decreased double-negative T cell number ( J:103922 )
• double-negative T cell numbers are similar to that in homozygous Rad50 mice
decreased macrophage cell number ( J:103922 )
• macrophage numbers are similar to that in homozygous Rad50 mice




Genotype
MGI:2450431
cx8
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:78820 )
• mean age of death is 4.5 months

neoplasm

immune system
immune system phenotype ( J:78820 )
N
• B cell numbers increased 5-20 fold compared to Rad50tm2Jpt homozygous mice

reproductive system
abnormal testis morphology ( J:78820 )
• suppression of testicular apoptosis
• normal meiotic progression

endocrine/exocrine glands
abnormal testis morphology ( J:78820 )
• suppression of testicular apoptosis
• normal meiotic progression

hematopoietic system




Genotype
MGI:3615669
cx9
Allelic
Composition		 Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (170 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm
increased lymphoma incidence ( J:103922 )
• 16 of 67 develop lymphoma

hematopoietic system
anemia ( J:103922 )
• most succumb to anemia
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

immune system
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice




Genotype
MGI:3615663
cx10
Allelic
Composition		 Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (170 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although die of malignancy, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 42% living longer than 5 months, 20.5% surviving to 10 months and 18% surviving to 15 months

neoplasm
increased lymphoma incidence ( J:103922 )
• although mutants develop lymphomas, the latency of lymphomagenesis is increased compared to homozygous Atmtm1Awb mice

cellular
cellular phenotype ( J:103922 )
N
• growth of MEFs and sensitivity to irradiation is comparable to wild-type indicating rescue of the slower growth of MEFs and increased sensitivity to gamma-irradiation that is seen in homozygous Atmtm1Awb mice
abnormal cell cycle checkpoint function ( J:103922 )
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
chromosome breakage ( J:103922 )
• exhibit some chromosomal instability, however it is slightly reduced relative to homozygous Atm mice

hematopoietic system
anemia ( J:103922 )
• 4 of 42 develop anemia




Genotype
MGI:3771145
cx11
Allelic
Composition		 Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:129762 )
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular
decreased apoptosis ( J:129762 )
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
anemia ( J:129762 )
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced




Genotype
MGI:3771144
cx12
Allelic
Composition		 Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:129762 )
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular
decreased apoptosis ( J:129762 )
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
anemia ( J:129762 )
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced




Genotype
MGI:3615682
cx13
Allelic
Composition		 Nbntm1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm1Jpt mutation (1 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:103922 )
N
• exhibit hematopoietic rescue of the abnormalities seen in homozygous Rad50tm2Jpt mice, with numbers of double-negative T cells, pro-B cells, and macrophages within 5-fold levels of wild-type levels




Genotype
MGI:3615681
cx14
Allelic
Composition		 Nbntm1Jpt/Nbntm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm1Jpt mutation (1 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:103922 )
N
• exhibit hematopoietic rescue of the abnormalities seen in homozygous Rad50tm2Jpt mice, with numbers of double-negative T cells, pro-B cells, and macrophages within 5-fold levels of wild-type levels




Genotype
MGI:3615680
cx15
Allelic
Composition		 Mre11atm1Jpt/Mre11a+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11atm1Jpt mutation (1 available); any Mre11a mutation (49 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• 32 of 49 die before 5 months of age, however survival time is increased compared to homozygous Rad50tm2Jpt mice, as 17 mutants survive past 5 months of age

hematopoietic system
abnormal hematopoietic system morphology/development ( J:103922 )
• 19 of the 32 mutants that die exhibited hematopoietic attrition
anemia ( J:103922 )
• 19 of the 32 mutants that die exhibit anemia

neoplasm
increased lymphoma incidence ( J:103922 )
• 10 of the 32 mutants that die succumb to lymphoma




Genotype
MGI:3615671
cx16
Allelic
Composition		 Mre11atm1Jpt/Mre11atm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11atm1Jpt mutation (1 available); any Mre11a mutation (49 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although some die prematurely, survival time is increased compared to homozygous Rad50tm2Jpt mice, with 24 of 29 alive at 5 months of age with no signs of anemia

neoplasm
increased lymphoma incidence ( J:103922 )
• 4 of 24 develop lymphoma

cellular
abnormal cell cycle checkpoint function ( J:103922 )
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
increased cellular sensitivity to ionizing radiation ( J:103922 )
• MEFs exhibit increased sensitivity to ionizing radiation

hematopoietic system
hematopoietic system phenotype ( J:103922 )
N
• do not observe hematopoietic cell attrition as in homozygous Rad50 mice, indicating rescue of hematopoietic defects




Genotype
MGI:3615683
cx17
Allelic
Composition		 Rad50tm2Jpt/Rad50tm2Jpt
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although mutants succumb to anemia, it is significantly later than in homozygous Rad50tm2Jpt mice, with all dying by 7.5 months of age

hematopoietic system
anemia ( J:103922 )
• although mutants succumb to anemia, it is significantly later than in homozygous Rad50tm2Jpt mice




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Send questions and comments to User Support. 		last database update
12/10/2024
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