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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otptm1Tlu
targeted mutation 1, Thomas Lufkin
MGI:2387865
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otptm1Tlu/Otptm1Tlu either: 129/Sv-Otptm1Tlu or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:3840994


Genotype
MGI:3840994
hm1
Allelic
Composition		 Otptm1Tlu/Otptm1Tlu
Genetic
Background		 either: 129/Sv-Otptm1Tlu or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otptm1Tlu mutation (0 available); any Otp mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:65759 )
• die within 3 days of birth

growth/size/body
decreased body size ( J:65759 )
• reduced body size
decreased body weight ( J:65759 )

nervous system
decreased brain size ( J:65759 )
• reduced by about 30%
abnormal diencephalon morphology ( J:65759 )
• regions surrounding the third ventricle are hypocellular
abnormal neurohypophysis morphology ( J:65759 )
• markedly depleted of cells
abnormal third ventricle morphology ( J:65759 )
• reduced volume
• thickened infundibulum
abnormal paraventricular hypothalamic nucleus morphology ( J:65759 )
• cell population not clearly identifiable
• area filled with densely packed with neurons similar to those in the anterior hypothalamic nucleus
abnormal supraoptic nucleus morphology ( J:65759 )
• hypocellular
• cell population not clearly identifiable
abnormal hypothalamus physiology ( J:65759 )
• decreased cell proliferation in the area of the paraventricular nucleus and the supraoptic nucleus starting around E11.5
• arginine vasopressin is not detectable in either the paraventricular nucleus or the supraoptic nucleus
• oxytocin is absent in the paraventricular nucleus and dramatically reduced in the supraoptic nucleus
• corticotropin releasing hormone is undetectable
• somatostatin neurons are undetectable at E13.5

endocrine/exocrine glands
abnormal neurohypophysis morphology ( J:65759 )
• markedly depleted of cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory