All Phenotypes Ogt<tm1Gwh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ogt^tm1Gwh
targeted mutation 1, Gerald W Hart
MGI:2387867

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ogt^tm1Gwh/Y	involves: 129S1/Sv * 129X1/SvJ	MGI:3841624
cn2	Ogt^tm1Gwh/Ogt⁺ Tg(Prm-cre)58Og/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3841629
cn3	Ogt^tm1Gwh/Ogt^tm1Gwh Tg(Zp3-cre)1Gwh/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3841621
cn4	Ogt^tm1Gwh/Ogt⁺ Tg(Zp3-cre)1Gwh/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3841622
cn5	Ogt^tm1Gwh/Y Tg(Zp3-cre)1Gwh/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3841623
cn6	Ogt^tm1Gwh/Y Tg(Lck-cre)548Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3841625
cn7	Ogt^tm1Gwh/Y Tg(Syn1-cre)671Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3841626
cn8	Ogt^tm1Gwh/Ogt^tm1Gwh Tg(Syn1-cre)671Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3841627

Allelic Composition	Ogt^tm1Gwh/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell death ( J:62279 , J:93112 )

• recombined embryonic stem cells are found at 24 and 48 h following cre transduction but by 144 h all viable cells carry the unrecombined allele (J:62279)

• primary embryonic fibroblasts infected with viral cre senesce and die by 12 days after infection (J:93112)

decreased cell proliferation ( J:93112 )

• primary embryonic fibroblasts infected with viral cre do not form colonies of more than 10 cells indicating a failure to undergo 4 or more cell divisions

Allelic Composition	Ogt^tm1Gwh/Ogt⁺ Tg(Prm-cre)58Og/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Prm-cre)58Og mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93112 )

• mice are viable and fertile with no gross abnormalities and expression levels of Ogt that are similar to controls suggesting inactivation of the paternal X chromosome in all tissues and cell types surveyed

• mice do not produce any offspring carrying the recombined allele

Allelic Composition	Ogt^tm1Gwh/Ogt^tm1Gwh Tg(Zp3-cre)1Gwh/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Zp3-cre)1Gwh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:62279 )

• when the cre is inherited maternally, no mice carrying the recombined allele are detected

reproductive system

female infertility ( J:93112 )

• when the cre is inherited paternally mice survive but females are infertile

Allelic Composition	Ogt^tm1Gwh/Ogt⁺ Tg(Zp3-cre)1Gwh/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Zp3-cre)1Gwh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:62279 )

• no mice carrying the recombined allele are detected

Allelic Composition	Ogt^tm1Gwh/Y Tg(Zp3-cre)1Gwh/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Zp3-cre)1Gwh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:62279 )

• no mice carrying the recombined allele are detected

Allelic Composition	Ogt^tm1Gwh/Y Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:93112 )

• increase in annexin-V expression in single positive T cells

decreased T cell number ( J:93112 )

• about a 75% reduction in the number of T cells in the lymph nodes and spleen

• no T cells carrying the recombined allele are found in the lymph nodes or spleen

decreased thymocyte number ( J:93112 )

• about a 50% reduction in thymocyte cell number

decreased double-positive T cell number ( J:93112 )

• cortical double positive T cells are reduced by 50%

decreased CD4-positive, alpha-beta T cell number ( J:93112 )

• reduced by 50%

decreased CD8-positive, alpha-beta T cell number ( J:93112 )

• reduced by 75%

hematopoietic system

increased T cell apoptosis ( J:93112 )

• increase in annexin-V expression in single positive T cells

decreased T cell number ( J:93112 )

• about a 75% reduction in the number of T cells in the lymph nodes and spleen

• no T cells carrying the recombined allele are found in the lymph nodes or spleen

decreased thymocyte number ( J:93112 )

• about a 50% reduction in thymocyte cell number

decreased double-positive T cell number ( J:93112 )

• cortical double positive T cells are reduced by 50%

decreased CD4-positive, alpha-beta T cell number ( J:93112 )

• reduced by 50%

decreased CD8-positive, alpha-beta T cell number ( J:93112 )

• reduced by 75%

cellular

increased T cell apoptosis ( J:93112 )

• increase in annexin-V expression in single positive T cells

endocrine/exocrine glands

decreased thymocyte number ( J:93112 )

• about a 50% reduction in thymocyte cell number

Allelic Composition	Ogt^tm1Gwh/Y Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:93112 )

• none survive for more than 10 days

prenatal lethality, incomplete penetrance ( J:93112 )

• found at only about 50% of the expected frequency

behavior/neurological

abnormal suckling behavior ( J:93112 )

• rarely nurse

abnormal locomotor behavior ( J:93112 )

• fail to develop normal locomotor activity

growth/size/body

decreased fetal size ( J:93112 )

Allelic Composition	Ogt^tm1Gwh/Ogt^tm1Gwh Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogt^tm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:93112 )

• none survive for more than 10 days

behavior/neurological

abnormal suckling behavior ( J:93112 )

• rarely nurse

abnormal locomotor behavior ( J:93112 )

• fail to develop normal locomotor activity

growth/size/body

decreased fetal size ( J:93112 )

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