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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpm1tm1Dfw
targeted mutation 1, David F Wieczorek
MGI:2387893
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tpm1tm1Dfw/Tpm1tm1Dfw involves: 129P2/OlaHsd * Black Swiss MGI:3623730
ht2
 		Tpm1tm1Dfw/Tpm1+ involves: 129P2/OlaHsd * Black Swiss MGI:3623731


Genotype
MGI:3623730
hm1
Allelic
Composition		 Tpm1tm1Dfw/Tpm1tm1Dfw
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm1tm1Dfw mutation (0 available); any Tpm1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:45833 )
• homozygotes die between E8 and E11.5




Genotype
MGI:3623731
ht2
Allelic
Composition		 Tpm1tm1Dfw/Tpm1+
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm1tm1Dfw mutation (0 available); any Tpm1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:45833 )
• heterozygotes are viable and fertile and exhibit no abnormalities in cardiac morphology or myocardial function, as shown by normal heart rates, intraventricular pressures, and rates of contraction and relaxation as well as normal Ca2+ activation of myofilaments in skinned fiber bundles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory