Phenotypes associated with this allele

• Allele Symbol: Msh2^tm1Whl
• Allele Name: targeted mutation 1, Wen-Hwa Lee
• Allele ID: MGI:2387935
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh2^tm1Whl/Msh2^tm1Whl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3834162
cx2	Msh2^tm1Whl/Msh2^tm1Whl Rb1^tm1Brd/Rb1^+	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:3834164
cx3	Msh2^tm1Whl/Msh2^tm1Whl Rb1^tm1Brd/Rb1^tm1Brd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:3834165

Genotype
MGI:3834162

hm1

• Allelic Composition: Msh2^tm1Whl/Msh2^tm1Whl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79016 )

• lymphomas are the predominant cause of death

neoplasm

increased gastrointestinal tumor incidence ( J:79016 )

• develop gastrointestinal tumors

• about 75% of mice develop small intestine tumors while about 33% develop large intestine tumors

increased lymphoblastic lymphoma incidence ( J:79016 )

• seen in about 75% of mice

increased skin tumor incidence ( J:79016 )

• skin tumors include a low differentiated squamous cell carcinoma and a basal cell tumor with sebaceous component

abnormal tumor morphology ( J:79016 )

• microsatellite instability is seen in all lymphomas and intestinal tumors

increased squamous cell carcinoma incidence ( J:79016 )

• skin tumors include a low differentiated squamous cell carcinoma

integument

increased skin tumor incidence ( J:79016 )

• skin tumors include a low differentiated squamous cell carcinoma and a basal cell tumor with sebaceous component

endocrine/exocrine glands

increased lymphoblastic lymphoma incidence ( J:79016 )

• seen in about 75% of mice

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:79016 )

• develop gastrointestinal tumors

• about 75% of mice develop small intestine tumors while about 33% develop large intestine tumors

immune system

increased lymphoblastic lymphoma incidence ( J:79016 )

• seen in about 75% of mice

hematopoietic system

increased lymphoblastic lymphoma incidence ( J:79016 )

• seen in about 75% of mice

Genotype
MGI:3834164

cx2

• Allelic Composition: Msh2^tm1Whl/Msh2^tm1Whl; Rb1^tm1Brd/Rb1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

mortality/aging

premature death ( J:79016 )

• life span is extended compared to mice homozygous for the Msh2 allele alone but shorter than that of mice heterozygous for the Rb allele alone

neoplasm

abnormal tumor morphology ( J:79016 )

• microsatellite instability is seen in all lymphomas and intestinal tumors but not in other tumor types

increased tumor incidence ( J:79016 )

• some mice develop soft tissue tumors (myxoid fibrosarcoma, hemangiosarcoma, and hemangioendothelioma)

increased gastrointestinal tumor incidence ( J:79016 )

• most mice develop gastrointestinal tumors

increased pheochromocytoma incidence ( J:79016 )

• seen in most mice

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

increased lymphoblastic lymphoma incidence ( J:79016 )

• apoptosis of lymphoma cells is increased compared to cells from mice homozygous for the Msh2 allele alone

increased thyroid C-cell carcinoma incidence ( J:79016 )

• most mice develop C cell thyroid carcinomas

increased skin tumor incidence ( J:79016 )

hematopoietic system

increased lymphoblastic lymphoma incidence ( J:79016 )

• apoptosis of lymphoma cells is increased compared to cells from mice homozygous for the Msh2 allele alone

abnormal definitive hematopoiesis ( J:79016 )

• ability of hematopoietic cells to rescue lethally irradiated mice is impaired although not as badly as for cells from double homozygous mice

integument

increased skin tumor incidence ( J:79016 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:79016 )

• most mice develop gastrointestinal tumors

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:79016 )

• seen in most mice

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

increased lymphoblastic lymphoma incidence ( J:79016 )

• apoptosis of lymphoma cells is increased compared to cells from mice homozygous for the Msh2 allele alone

increased thyroid C-cell carcinoma incidence ( J:79016 )

• most mice develop C cell thyroid carcinomas

nervous system

increased pituitary adenohypophysis tumor incidence ( J:79016 )

• some mice develop tumors of the pituitary anterior lobe

increased pituitary melanotroph tumor incidence ( J:79016 )

• all mice develop melanotroph tumors of the pituitary

immune system

increased lymphoblastic lymphoma incidence ( J:79016 )

• apoptosis of lymphoma cells is increased compared to cells from mice homozygous for the Msh2 allele alone

Genotype
MGI:3834165

cx3

• Allelic Composition: Msh2^tm1Whl/Msh2^tm1Whl; Rb1^tm1Brd/Rb1^tm1Brd
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

hematopoietic system

abnormal definitive hematopoiesis ( J:79016 )

• ability of hematopoietic cells to rescue lethally irradiated mice is impaired