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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iqgap1tm1Aber
targeted mutation 1, Andre Bernards
MGI:2387945
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iqgap1tm1Aber/Iqgap1tm1Aber involves: 129S4/SvJae * C57BL/6 MGI:3029425
cx2
 		Iqgap1tm1Aber/Iqgap1tm1Aber
Iqgap2tm1Vs/Iqgap2tm1Vs 		involves: 129S4/SvJae MGI:3777247


Genotype
MGI:3029425
hm1
Allelic
Composition		 Iqgap1tm1Aber/Iqgap1tm1Aber
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap1tm1Aber mutation (1 available); any Iqgap1 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal stomach mucosa morphology ( J:59215 )
• older mice exhibit hyperplasia and dysplasia of the mucosal layer of the stomach
disorganized stomach mucosa ( J:59215 )
• mucosal dysplasia observed in older mice




Genotype
MGI:3777247
cx2
Allelic
Composition		 Iqgap1tm1Aber/Iqgap1tm1Aber
Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap1tm1Aber mutation (1 available); any Iqgap1 mutation (102 available)
Iqgap2tm1Vs mutation (1 available); any Iqgap2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocellular carcinoma incidence ( J:132670 )
• incidence is decreased compared to Iqgap1tm1Vs single homozygotes but is increased compared to controls

mortality/aging
mortality/aging ( J:132670 )
N
• unlike Iqgap1tm1Vs single homozygotes, survival durations are not significantly different from controls

neoplasm
increased hepatocellular carcinoma incidence ( J:132670 )
• incidence is decreased compared to Iqgap1tm1Vs single homozygotes but is increased compared to controls
decreased tumor growth/size ( J:132670 )
• when present hepatocellular carcinomas are smaller than those in Iqgap1tm1Vs single homozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:132670 )
N
• unlike Iqgap2tm1Vs single homozygotes, levels of aspartate transaminase are similar to controls in mice at 4 and 8 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory