All Phenotypes H2-Ab1<b-tm1Hpl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2-Ab1^b-tm1Hpl
targeted mutation 1, Hidde Ploegh
MGI:2387946

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	H2-Ab1^b-tm1Hpl/H2-Ab1⁺	involves: 129S4/SvJae	MGI:3818328
cx2	Cx3cr1^tm1Litt/Cx3cr1^tm1Litt H2-Ab1^b-tm1Hpl/H2-Ab1⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:4833982

Allelic Composition	H2-Ab1^b-tm1Hpl/H2-Ab1⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Hpl mutation (1 available); any H2-Ab1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:78940 )

• mice are immunologically indistinguishable from wild-type controls

Allelic Composition	Cx3cr1^tm1Litt/Cx3cr1^tm1Litt H2-Ab1^b-tm1Hpl/H2-Ab1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Litt mutation (6 available); any Cx3cr1 mutation (45 available)
H2-Ab1^b-tm1Hpl mutation (1 available); any H2-Ab1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to infection ( J:95694 )

• S. typhimurium-infected mice exhibit a large number of bacteria in the GFP- phagocyte subset unlike in similarly treated heterozygous mice and fewer bacteria are recovered from lamina propria dendritic cells

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