Phenotypes associated with this allele

• Allele Symbol: Crlf1^tm1Wsa
• Allele Name: targeted mutation 1, Warren S Alexander
• Allele ID: MGI:2387956
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crlf1^tm1Wsa/Crlf1^tm1Wsa	involves: 129S1/Sv * C57BL/6	MGI:3618102

Genotype
MGI:3618102

hm1

• Allelic Composition: Crlf1^tm1Wsa/Crlf1^tm1Wsa
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:55482 )

• at birth, homozygotes are present at the expected Mendelian frequency; however, no homozygotes survive beyond 24 hrs after birth

behavior/neurological

absent gastric milk in neonates ( J:55482 )

• newborn homozygotes contain no milk in their stomachs

abnormal suckling behavior ( J:55482 )

• newborn homozygotes open and close their mouths but fail to suckle effectively, despite the absence of gross or histologic abnormalities in brain (i.e. cortex and hippocampus), olfactory bulb, as well as facial or mouth tissues

nervous system

decreased motor neuron number ( J:85998 )

• newborn homozygotes display a significantly reduced number of motoneurons in the lumbar spinal cord, with no apparent change in the brachial or thoracic cord

• newborn homozygotes also exhibit a significant decrease in the number of motoneurons in the facial but not hypoglossal nucleus; sensory neurons of the dorsal root ganglia remain unaffected

hematopoietic system

impaired hematopoiesis ( J:55482 )

• newborn homozygotes display reduced numbers of hemopoietic progenitor cells in the bone marrow and spleen

• no differences in the numbers and lineage commitment of progenitor cells are observed in neonatal liver