Phenotypes associated with this allele

• Allele Symbol: Kcnc2^tm1Rudy
• Allele Name: targeted mutation 1, Bernardo Rudy
• Allele ID: MGI:2387957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnc2^tm1Rudy/Kcnc2^tm1Rudy	B6.129S1-Kcnc2^tm1Rudy	MGI:3583223

Genotype
MGI:3583223

hm1

• Allelic Composition: Kcnc2^tm1Rudy/Kcnc2^tm1Rudy
• Genetic Background: B6.129S1-Kcnc2^tm1Rudy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:66730 )

increased susceptibility to pharmacologically induced seizures ( J:66730 )

• using Pentylenetetrazole

myoclonus ( J:66730 )

• spontaneous seizures characterized as tonic-clonic convulsions

tonic-clonic seizures ( J:66730 )

• spontaneous seizures characterized as tonic-clonic convulsions

sporadic seizures ( J:66730 )

• low level of spontaneous epileptic episodes

• 14 mice out of several hundred handled

abnormal nervous system electrophysiology ( J:66730 )

abnormal action potential ( J:66730 )

• fast-spike cortical interneurons from deep layers but not superficial layers with broader action potentials and slower repolarization

• fast-spike neurons unable to sustain high frequencies of firing with repetitive stimulation

• unable to generate rhythmic spike doublets on stimulation

abnormal afterhyperpolarization ( J:66730 )

• reduced by about 25% and slower

abnormal brain wave pattern ( J:66730 )

• irregular EEG slow rhythm

behavior/neurological

increased anxiety-related response ( J:66730 )

• center/distance ratio is lower in open field tests

abnormal sleep pattern ( J:78965 )

• lower frequency of NREM and REM sleep although episode duration was normal

• lower EEG power density in NREM sleep, also in the frontal derivation during REM sleep

seizures ( J:66730 )

increased susceptibility to pharmacologically induced seizures ( J:66730 )

• using Pentylenetetrazole

myoclonus ( J:66730 )

• spontaneous seizures characterized as tonic-clonic convulsions

tonic-clonic seizures ( J:66730 )

• spontaneous seizures characterized as tonic-clonic convulsions

sporadic seizures ( J:66730 )

• low level of spontaneous epileptic episodes

• 14 mice out of several hundred handled

muscle

myoclonus ( J:66730 )

• spontaneous seizures characterized as tonic-clonic convulsions