Phenotypes associated with this allele

• Allele Symbol: Grin3a^tm1Nnk
• Allele Name: targeted mutation 1, Nobuki Nakanishi
• Allele ID: MGI:2387963
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin3a^tm1Nnk/Grin3a^tm1Nnk	either: (involves: 129S/SvEv * 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)	MGI:3639146
hm2	Grin3a^tm1Nnk/Grin3a^tm1Nnk	involves: 129X1/SvJ * Black Swiss * C57BL/6	MGI:3639147

Genotype
MGI:3639146

hm1

• Allelic Composition: Grin3a^tm1Nnk/Grin3a^tm1Nnk
• Genetic Background: either: (involves: 129S/SvEv * 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendrite morphology ( J:66481 )

• increased number and density of dendritic spines in cerebrocortical layer IV and V neurons

• number of dendrite branches and lengths are normal

• heads of dendritic spines are enlarged and necks are elongated

• abnormalities are more apparent at 19 days of age than in adults

abnormal single cell response ( J:66481 )

• N-methyl-D-aspartate induced current density in dissociated cerbrocortical neurons is 2.8X greater than in controls

vision/eye

abnormal eye electrophysiology ( J:85752 )

• N-methyl-D-aspartate evoked calcium responses in retinal cells are greater than in cells of controls

Genotype
MGI:3639147

hm2

• Allelic Composition: Grin3a^tm1Nnk/Grin3a^tm1Nnk
• Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

nervous system

abnormal prepulse inhibition ( J:102120 )

• males show an increased prepulse inhibition with no change in startle response magnitude after stimulation

behavior/neurological

behavior/neurological phenotype ( J:102120 )

N • no changes were seen in the magnitude of startle responses in either males or females