Phenotypes associated with this allele

• Allele Symbol: Tcl1^tm1Rso
• Allele Name: targeted mutation 1, Giandomenico Russo
• Allele ID: MGI:2387964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcl1^tm1Rso/Tcl1^tm1Rso	involves: 129X1/SvJ * C57BL/6	MGI:2675314

Genotype
MGI:2675314

hm1

• Allelic Composition: Tcl1^tm1Rso/Tcl1^tm1Rso
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:78910 )

♀ • homozygous females exhibit a reduced litter size; progressive severity with age

♀ • females exhibit normal oogenesis and fertilization; however, the oocytes derived from homozygous females exhibit an impaired ability to undergo normal cleavage and develop to the morula stage after fertilization

decreased litter size ( J:78910 )

• litters derived from homozygous females are consistently smaller in size; litters from homozygous males are not affected, unless in combination with homozygous females; progressive severity with age