Phenotypes associated with this allele

• Allele Symbol: Ptger1^tm1Jdm
• Allele Name: targeted mutation 1, John D McNeish
• Allele ID: MGI:2387971
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptger1^tm1Jdm/Ptger1^tm1Jdm	DBA/1LacJ-Ptger1^tm1Jdm	MGI:3589906

Genotype
MGI:3589906

hm1

• Allelic Composition: Ptger1^tm1Jdm/Ptger1^tm1Jdm
• Genetic Background: DBA/1LacJ-Ptger1^tm1Jdm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:79387 )

N • significantly fewer homozygotes (13.7% versus predicted 25%) are obtained by intercrossing heterozygotes (onset of lethality is not specified)

N • however, homozygotes appear morphologically normal and healthy, with no evidence of renal anomalies or other histopathological changes in major organ systems

immune system

immune system phenotype ( J:72198 , J:78964 )

N • in the MLR model of cellular alloimmune response, PGE2 causes potent inhibition of allospecific proliferation by homozygous null lymphocytes; this effect is essentially identical to that observed in wild-type responder cells (J:72198)

N • at day 10, homozygotes show no significant differences in the course or severity of collagen antibody-induced rheumatoid arthritis relative to their respective genetic wild-type controls, based on paw swelling/redness and joint ankylosis (J:78964)

reproductive system

reproductive system phenotype ( J:79387 )

N • notably, homozygotes show no significant differences in reproductive function relative to wild-type mice

behavior/neurological

increased chemical nociceptive threshold ( J:79387 )

• homozygotes exhibit a ~50% reduction in nociceptive perception in the acetic acid-induced stretch model of algesia

• piroxicam treatment fails to significantly inhibit pain sensation and reduce acetic acid-induced stretching

abnormal nociception after inflammation ( J:79387 )

• homozygotes show a ~50% reduction in nociceptive pain perception in two acute prostaglandin-dependent models of algesia (acetic acid-induced and PBQ-induced stretching assays)

• however, homozygotes exhibit no significnat differences in the concentration of PGE2 or prostacyclin in peritoneal lavage fluid after acetic acid treatment

cardiovascular system

increased heart rate ( J:79387 )

• male homozygotes show significantly increased pulse rates (732 7 beats/minute; n=10) relative to wild-type males (694 9 beats/minute; n=10)

decreased systemic arterial blood pressure ( J:79387 )

• male homozygotes exhibit a >10 mmHg reduction in systolic blood pressure relative to wild-type males

• mean systolic blood pressures are decreased by an additional 8 mmHg on a low-salt diet

• female homozygotes tend to display lower systolic blood pressures; however, this difference does not reach statistical significance

homeostasis/metabolism

increased renin activity ( J:79387 )

• male (but not female) homozygotes exhibit significantly increased kidney renin mRNA levels and plasma renin activity relative to wild-type males