Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ksr1tm1Shaw targeted mutation 1, Andrey S Shaw MGI:2387975 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• identical fat pad weights suggest mice have fewer but larger adipocytes
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• marked increase in cross sectional area of adipocytes in epididymal fat tissue
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• MEFs treated with an adipogenic cocktail fail to differentiate into adipocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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• swelling of ankles and forepaws induced by injection of serum from mice transgenic for Tg(TcraR28,TcrbR28)KRNDim is significantly reduced compared to controls
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| N |
• no abnormalities in motor activity or anxiety like behavior are detected
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the context or cue but no defect is detected when reexposure occurs 1 hour after training suggesting an impairment in long term memory
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the context
• however, no defect is detected when a more intense training protocol is used or when testing is done 1 hour after training
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the cue
• however, no defect is detected when a more intense training protocol is used or when testing is done 1 hour after training
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• in a probe trial of a Morris water maze 7 days after training mice display fewer platform crossings but spend a similar amount of time in the target quadrant compared to controls
• 24 hours after training latency to enter the dark side (where a shock was given during training) is reduced compared to controls
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• cell body spiking following the first train of theta burst is significantly reduced compared to controls
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• decrease in theta burst stimulated long term potentiation, especially in the first hour post induction
• however, long term potentiation in response to 2 high frequency stimulations is similar to controls
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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• swelling of ankles and forepaws induced by injection of serum from mice transgenic for Tg(TcraR28,TcrbR28)KRNDim is significantly reduced compared to controls
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased T cell proliferation when stimulated with ovalbumin peptide
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• cultured T cells under conditions that promote either Th1 or Th2 differentiation fail to produce appreciable amounts of IFNG or IL4
• addition of supplemental IL2 allows for normal Th1 and Th2 differentiation
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• at 24, 48, and 72 h after stimulation compared to controls
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• decreased T cell proliferation when stimulated with ovalbumin peptide
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• cultured T cells under conditions that promote either Th1 or Th2 differentiation fail to produce appreciable amounts of IFNG or IL4
• addition of supplemental IL2 allows for normal Th1 and Th2 differentiation
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• decreased T cell proliferation when stimulated with ovalbumin peptide
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• onset of tumor formation is delayed with no mammary tumors detected until 65 +/- 9 days of age compared to 35 +/- 8 days of age for heterozygous controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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