Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nrcamtm1Gmt targeted mutation 1, Martin Grumet MGI:2387976 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lobes IV and V of the cerebellum are smaller in Nrcamtm1Gmt/Nrcamtm1Gmt mice
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• reduced size of lobes IV and V; these lobes contained 11% less gray matter than control littermates; lobes I, II and X are also slightly reduced in size
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• isolated cerebellar cells fail to extend neurites in response to contactin, however neurites still extend in response to RPTPbeta
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• sodium ion channels are absent from heminodes unlike in wild-type mice
• heminodes fail to form unlike in wild-type mice
• however, nodes form normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males and females display a longer latency to reach the escape platform in the reversal phase
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• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials
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• females but not males display a longer latency to find a hidden platform
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• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females
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• decrease in rearing frequency in an open field in females
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• males fail to show a preference for a stranger mouse over an empty cage
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• small but significant decrease in males
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:153165 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• sodium ion channels are absent from heminodes unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P8
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• nodes and heminodes fail to form unlike in wild-type mice
• nodal length is increased compared to in wild-type mice
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• at P7
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in rate of postnatal death, especially during the first 1-2 weeks after birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Cerebellar abnormalities in L1camtm1Sor/Y Nrcamtm1Gmt/Nrcamtm1Gmt mice
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• do not detect any mutants at P8
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• body weights of pups are 40-70% of control littermates at P3-P6
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• cerebellar dysgenesis
• cerebellar fissures are less developed
• thickness of the inner granule layer is reduced by 40-50%
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• marker analysis indicates defects in foliation
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• thickness of the external granule layer is reduced by 10-30%
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• cerebellar lobes are less developed
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• marker analysis indicates possible defects in granule cells during cerebellar development
• thickness of the inner granule layer is reduced by 40-50%
• thickness of the external granule layer is reduced by 10-30%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in rate of postnatal death, especially during the first 1-2 weeks after birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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