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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lpar2tm1Jch
targeted mutation 1, Jerold Chun
MGI:2387979
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lpar2tm1Jch/Lpar2tm1Jch involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2684650
cx2
 		Plppr4tm1Roni/Plppr4tm1Roni
Lpar2tm1Jch/Lpar2tm1Jch 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4431244
cx3
 		Lpar1tm1Jch/Lpar1tm1Jch
Lpar2tm1Jch/Lpar2tm1Jch 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7861271


Genotype
MGI:2684650
hm1
Allelic
Composition		 Lpar2tm1Jch/Lpar2tm1Jch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpar2tm1Jch mutation (0 available); any Lpar2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:78925 )
N
• mice are grossly indistinguishable from littermates in terms of longevity

reproductive system
reproductive system phenotype ( J:78925 )
N
• mice exhibit no reproductive phenotypes

growth/size/body
growth/size/body region phenotype ( J:78925 )
N
• mice are grossly indistinguishable from littermates in appearance and size

behavior/neurological
behavior/neurological phenotype ( J:78925 )
N
• mice exhibit normal behavior

cardiovascular system
cardiovascular system phenotype ( J:275252 )
N
• after i.v. injection of lysophosphatidic acid (18:1-LPA, 1.4 mg/kg), mice show a normal LPA-induced transient hypertensive response relative to similarly treated wild-type controls




Genotype
MGI:4431244
cx2
Allelic
Composition		 Plppr4tm1Roni/Plppr4tm1Roni
Lpar2tm1Jch/Lpar2tm1Jch
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpar2tm1Jch mutation (0 available); any Lpar2 mutation (13 available)
Plppr4tm1Roni mutation (0 available); any Plppr4 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157318 )
N
• mice do not exhibit increased mortality around P21

nervous system
nervous system phenotype ( J:157318 )
N
• mice do not exhibit seizure activity or epileptic discharge
abnormal miniature excitatory postsynaptic currents ( J:157318 )
• CA1 pyramidal cells exhibit a reduced miniature excitatory postsynaptic current frequency compared to in wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:157318 )
N
• mice do not exhibit seizure activity or epileptic discharge

growth/size/body
growth/size/body region phenotype ( J:157318 )
N
• mice exhibit normal body weight




Genotype
MGI:7861271
cx3
Allelic
Composition		 Lpar1tm1Jch/Lpar1tm1Jch
Lpar2tm1Jch/Lpar2tm1Jch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpar1tm1Jch mutation (0 available); any Lpar1 mutation (71 available)
Lpar2tm1Jch mutation (0 available); any Lpar2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:275252 )
N
• after i.v. injection of lysophosphatidic acid (18:1-LPA, 1.4 mg/kg), double knockout mice show a normal LPA-induced transient hypertensive response relative to similarly treated controls




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory