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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smarca2tm1Mya
targeted mutation 1, Moshe Yaniv
MGI:2387988
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smarca2tm1Mya/Smarca2tm1Mya involves: 129S2/SvPas MGI:2661968
hm2
 		Smarca2tm1Mya/Smarca2tm1Mya involves: 129S2/SvPas * C57BL/6 MGI:3028661
ht3
 		Smarca2tm1Mya/Smarca2+ involves: 129S2/SvPas MGI:2661967
cn4
 		Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(KRT14-cre/ERT2)1Ipc/? 		involves: 129S2/SvPas MGI:3606862
cn5
 		Smarca2tm1Mya/Smarca2+
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009696
cn6
 		Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009697
cx7
 		Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.1Pcn/Smarca4+ 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009695
cx8
 		Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1Mag/Smarca4+ 		involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1 MGI:5763443


Genotype
MGI:2661968
hm1
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
infertility ( J:51536 )
• 20% of mating pairs failed to produce offspring; this phenotype observed only in homozygous x homozygous mating pairs

muscle
abnormal muscle physiology ( J:172661 )
• in neonates, intestinal smooth muscle cell proliferation is increased compared to in wild-type mice
• however, apoptosis in intestinal smooth muscle cells is normal

growth/size/body
increased body weight ( J:51536 )
• homozygotes were on average 14% heavier than wild-type; increased weight may be due to defects in cellular proliferation as demonstrated in mutant liver tissue and embryonic fibroblasts

skeleton
skeleton phenotype ( J:51536 )
N
• no skeletal defects found in whole mount skeletal preparations




Genotype
MGI:3028661
hm2
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
infertility ( J:51536 )
• 20% of mating pairs failed to produce offspring; this phenotype observed only in homozygous x homozygous mating pairs

skeleton
skeleton phenotype ( J:51536 )
N
• no skeletal defects found in whole mount skeletal preparations




Genotype
MGI:2661967
ht3
Allelic
Composition		 Smarca2tm1Mya/Smarca2+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:51536 )
• heterozygotes were of intermediate average weight between homozygous mutant and wild-type mice




Genotype
MGI:3606862
cn4
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(KRT14-cre/ERT2)1Ipc/?
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired skin barrier function ( J:101729 )
• regardless of when tamoxifen induction occurred
• very severely affected

integument
impaired skin barrier function ( J:101729 )
• regardless of when tamoxifen induction occurred
• very severely affected
abnormal skin morphology ( J:101729 )
• regardless of when tamoxifen induction occurred
abnormal epidermis stratum corneum morphology ( J:101729 )
• only 1-2 cornified cell layers present
abnormal epidermis stratum granulosum morphology ( J:101729 )
• swollen cytoplasm and nuclei
enlarged spinous cells ( J:101729 )
• swollen cytoplasm and nuclei




Genotype
MGI:5009696
cn5
Allelic
Composition		 Smarca2tm1Mya/Smarca2+
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
enlarged cecum ( J:172661 )
• by 4 weeks of age
decreased colon length ( J:172661 )
• the colon is shorter than in wild-type mice
megacolon ( J:172661 )
• by 4 weeks of age
abnormal small intestine morphology ( J:172661 )
• enlarged by 4 weeks of age
decreased small intestine length ( J:172661 )
• mice exhibit short smaller intestine




Genotype
MGI:5009697
cn6
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:172661 )
• fewer than expected mice are present at P10
• no mice survives beyond 2 weeks

digestive/alimentary system
abnormal digestive system morphology ( J:172661 )
• by 7 to 10 days, all mice develop enlarged gastrointestinal tract unlike control mice
abnormal intestine morphology ( J:172661 )
• mice exhibit dilated intestines filled with air and fecal matter unlike control mice
abnormal intestinal smooth muscle morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice
abnormal small intestine morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice

muscle
abnormal intestinal smooth muscle morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice
abnormal muscle physiology ( J:172661 )
• in neonates, smooth muscle cell apoptosis in the proximal and distal colon is increased compared to in control mice
• however, proliferation of intestinal smooth muscle cell is equivalent to in wild-type mice
impaired smooth muscle contractility ( J:172661 )
• cannulated colonic segments fail to exhibit spontaneous contractile activity compared with control tissue

renal/urinary system
abnormal urinary bladder morphology ( J:172661 )
• by 7 to 10 days, all mice exhibit enlarged urinary bladder unlike control mice




Genotype
MGI:5009695
cx7
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.1Pcn/Smarca4+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:172661 )
N
• mice exhibit normal intestines and colonic ring contractility

muscle
abnormal muscle physiology ( J:172661 )
• in neonates, intestinal smooth muscle cell proliferation is increased compared to in wild-type mice
• however, colonic ring contractility is normal




Genotype
MGI:5763443
cx8
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1Mag/Smarca4+
Genetic
Background		 involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1Mag mutation (1 available); any Smarca4 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased mammary gland tumor incidence ( J:132091 )
• one female develops a mammary tumor at 14 months of age

integument
increased mammary gland tumor incidence ( J:132091 )
• one female develops a mammary tumor at 14 months of age

neoplasm
increased mammary gland tumor incidence ( J:132091 )
• one female develops a mammary tumor at 14 months of age
increased hemangiosarcoma incidence ( J:132091 )
• one male develops a hemangiosarcoma at 16 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory