About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1tm1Jrc
targeted mutation 1, J Richard Chaillet
MGI:2387992
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt1tm1Jrc/Dnmt1tm1Jrc involves: 129S1/Sv MGI:3795496
hm2
 		Dnmt1tm1Jrc/Dnmt1tm1Jrc involves: 129S1/Sv * FVB/N MGI:3795495


Genotype
MGI:3795496
hm1
Allelic
Composition		 Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jrc mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
female infertility ( J:68455 )
• female mice are infertile and fail to produce embryos that survive beyond early fetal or neonatal development

cellular
abnormal imprinting ( J:68455 )
• heterozygous offspring of homozygous female mice exhibit abnormal imprinting
• however, global methylation is unchanged




Genotype
MGI:3795495
hm2
Allelic
Composition		 Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jrc mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal imprinting ( J:135338 )
• differential methylation patterns are not maintained unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory