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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mxd1tm1Rne
targeted mutation 1, Robert N Eisenman
MGI:2387993
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mxd1tm1Rne/Mxd1tm1Rne involves: 129S4/SvJaeSor * C57BL/6 MGI:3796419


Genotype
MGI:3796419
hm1
Allelic
Composition
Mxd1tm1Rne/Mxd1tm1Rne
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mxd1tm1Rne mutation (0 available); any Mxd1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice produce normal levels of serum immunoglobulins and show no increased level of spontaneous infection when housed in non-pathogen-free conditions
• myeloid clls from bone marrow show increased sensitivity to apoptosis-inducing stimuli and decreased survival ability under limiting cytokine conditions compared to wild-type
• increased frequency of mature granulocytes in bone marrow of mutants compared to wild-type
• increased frequency (3-fold) of granulocytic cluster-forming cells bone marrow culture stimulated with G-CSF
• after 5-fluorouracil ablation of proliferating bone marrow precursors, mature peripheral blood and splenic granulocyes recover to higher levels than in wild-type by 14 days post-treatment, and increased numbers of granulocyte cluster-forming cells are found in bone marrow and spleen
• in vitro stimulation with LPS results in resting B lymphocytes re-entering the cell cycle more rapidly than wild-type cells

hematopoietic system
• frequency of granulocytic precursors of promyelocyte/myelocyte morphology is increased in bone marrow compared to wild-type
• myeloid clls from bone marrow show increased sensitivity to apoptosis-inducing stimuli and decreased survival ability under limiting cytokine conditions compared to wild-type
• increased frequency of mature granulocytes in bone marrow of mutants compared to wild-type
• increased frequency (3-fold) of granulocytic cluster-forming cells bone marrow culture stimulated with G-CSF
• after 5-fluorouracil ablation of proliferating bone marrow precursors, mature peripheral blood and splenic granulocyes recover to higher levels than in wild-type by 14 days post-treatment, and increased numbers of granulocyte cluster-forming cells are found in bone marrow and spleen
• in vitro stimulation with LPS results in resting B lymphocytes re-entering the cell cycle more rapidly than wild-type cells





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory