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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nodaltm3Rob
targeted mutation 3, Elizabeth J Robertson
MGI:2388004
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nodaltm3Rob/Nodaltm3Rob Not Specified MGI:3796339
ht2
 		Nodaltm1.2Rob/Nodaltm3Rob involves: 129S/SvEv * MF1 MGI:3796340


Genotype
MGI:3796339
hm1
Allelic
Composition		 Nodaltm3Rob/Nodaltm3Rob
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm3Rob mutation (0 available); any Nodal mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:79098 )
• homozygotes are born at Mendelian frequency from heterozygous intercrosses




Genotype
MGI:3796340
ht2
Allelic
Composition		 Nodaltm1.2Rob/Nodaltm3Rob
Genetic
Background		 involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.2Rob mutation (0 available); any Nodal mutation (42 available)
Nodaltm3Rob mutation (0 available); any Nodal mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:79098 )
• mutants are born alive but die within a few hours of birth

growth/size/body
heterotaxia ( J:79098 )
• positioning of stomach is randomized in mutants at birth whereas stomach is on the left side of abdominal cavity in wild-type
right pulmonary isomerism ( J:79098 )
• mutants have 4 lung lobes on the right and 3 or 4 on the left
situs ambiguus ( J:79098 )

cardiovascular system
abnormal heart development ( J:79098 )
• at birth, apex of heart points to left, middle, or right of thoracic cavity instead of the left as in controls
abnormal direction of heart looping ( J:79098 )
• in embryos at 9.0 days, direction is randomized
transposition of great arteries ( J:79098 )
• seen in most mutants at birth
atrial septal defect ( J:79098 )
• atrial septal defects are found in most mutants at birth
common atrium ( J:79098 )
• major defect observed in all mutants is development of single common atrial chamber rather than separate left or right atria

respiratory system
right pulmonary isomerism ( J:79098 )
• mutants have 4 lung lobes on the right and 3 or 4 on the left

hematopoietic system
small spleen ( J:79098 )
• all compound heterozygotes have spleens that are reduced in size relative to controls

immune system
small spleen ( J:79098 )
• all compound heterozygotes have spleens that are reduced in size relative to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory