normal phenotype
• homozygotes are born at Mendelian frequency from heterozygous intercrosses
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Allele Symbol Allele Name Allele ID |
Nodaltm3Rob targeted mutation 3, Elizabeth J Robertson MGI:2388004 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes are born at Mendelian frequency from heterozygous intercrosses
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mutants are born alive but die within a few hours of birth
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• positioning of stomach is randomized in mutants at birth whereas stomach is on the left side of abdominal cavity in wild-type
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• mutants have 4 lung lobes on the right and 3 or 4 on the left
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• at birth, apex of heart points to left, middle, or right of thoracic cavity instead of the left as in controls
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• in embryos at 9.0 days, direction is randomized
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• seen in most mutants at birth
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• atrial septal defects are found in most mutants at birth
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• major defect observed in all mutants is development of single common atrial chamber rather than separate left or right atria
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• mutants have 4 lung lobes on the right and 3 or 4 on the left
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• all compound heterozygotes have spleens that are reduced in size relative to controls
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• all compound heterozygotes have spleens that are reduced in size relative to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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