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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mbd3tm1Bh
targeted mutation 1, Brian Hendrich
MGI:2388006
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mbd3tm1Bh/Mbd3tm1Bh involves: 129P2/OlaHsd * C57BL/6 MGI:3579840
cx2
 		Mbd2tm1Bh/Mbd2tm1Bh
Mbd3tm1Bh/Mbd3+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3579841


Genotype
MGI:3579840
hm1
Allelic
Composition		 Mbd3tm1Bh/Mbd3tm1Bh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd3tm1Bh mutation (0 available); any Mbd3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:68356 )
• no normal embryos detectable after implantation
• at E8.5, embryos are severely retarded and undergoing resorption
• no live homozygotes born




Genotype
MGI:3579841
cx2
Allelic
Composition		 Mbd2tm1Bh/Mbd2tm1Bh
Mbd3tm1Bh/Mbd3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd2tm1Bh mutation (1 available); any Mbd2 mutation (21 available)
Mbd3tm1Bh mutation (0 available); any Mbd3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:68356 )
• surviving heterozygotes reduced by 30% from expected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory