Phenotypes associated with this allele

• Allele Symbol: Ambp^tm1Kkm
• Allele Name: targeted mutation 1, Koji Kimata
• Allele ID: MGI:2388018
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ambp^tm1Kkm/Ambp^tm1Kkm	involves: 129P2/OlaHsd * C57BL/6	MGI:2450556

Genotype
MGI:2450556

hm1

• Allelic Composition: Ambp^tm1Kkm/Ambp^tm1Kkm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired cumulus expansion and oocyte fertilization in Ambp^tm1Kkm/Ambp^tm1Kkm female mice

behavior/neurological

abnormal maternal nurturing ( J:68027 )

♀ • pups not transferred to heterozygous mutant foster mothers died within 2 days

embryo

failure of zygotic cell division ( J:68027 )

• reduced number of zygotes in oviducts at 0.5 dpc; failure of cleavage observed at 1.5 dpc

endocrine/exocrine glands

absent cumulus expansion ( J:68027 )

♀ • failure of cumulus expansion; cumulus cells were present in graffian follicles, but a cumulus oophorous matrix fails to form and the cells are dispersed in the vesicular ovarian follicle

reproductive system

abnormal oocyte morphology ( J:68027 )

♀ • intact zona pellucida; reduced number of oocytes in oviducts at 0.5 dpc and failure of cleavage observed at 1.5 dpc

absent cumulus expansion ( J:68027 )

♀ • failure of cumulus expansion; cumulus cells were present in graffian follicles, but a cumulus oophorous matrix fails to form and the cells are dispersed in the vesicular ovarian follicle

female infertility ( J:68027 )

♀

reduced female fertility ( J:68027 )

♀ • 50% of females that copulated became pregnant; severely reduced fertilty attributed to impaired fertilization of oocytes lacking an intact cumulus oophorous

decreased litter size ( J:68027 )

impaired fertilization ( J:68027 )

• ovulated oocytes are completely devoid of extracellular hyaluronan-rich matrix and remain unfertilized

cellular

abnormal oocyte morphology ( J:68027 )

♀ • intact zona pellucida; reduced number of oocytes in oviducts at 0.5 dpc and failure of cleavage observed at 1.5 dpc