Phenotypes associated with this allele

• Allele Symbol: Penk^tm1Dwp
• Allele Name: targeted mutation 1, D W Pfaff
• Allele ID: MGI:2388020
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Penk^tm1Dwp/Penk^tm1Dwp	involves: 129 * C57BL/6J	MGI:3814211

Genotype
MGI:3814211

hm1

• Allelic Composition: Penk^tm1Dwp/Penk^tm1Dwp
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:67551 )

• after ovariectomy, female mutants show higher mortality than wild-type or heterozygous controls

behavior/neurological

abnormal cued conditioning behavior ( J:67551 )

• female ovariectomized mutants exhibit significantly more freezing to the conditioned stimulus (auditory) before the unconditioned stimulus (shock) on day 2 of conditioning than control mice; freezing was significantly greater after shock on day 2 compared to freezing levels on day 1 or to wild-type and heterozygous controls

• male mutants were not tested

increased anxiety-related response ( J:67551 )

• female mice show decreased time in center of an open-field chamber compared to controls with lower amount of locomotion relative to controls

homeostasis/metabolism

delayed wound healing ( J:67551 )

• after ovariectomy, female mutants take longer to heal than wild-type or heterozygous controls