Analysis Tools
mortality/aging
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• fewer embryos are found at E10.5 and all are dead by E11.5
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embryo
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• at E9.5 none of the embryos have completed axial rotation
• at E10.5, only 1/3 of surviving embryos have undergone axial rotation
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• at E10.5 2/3 of surviving embryos have not turned
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• most unrotated embryos at E10.5 are caudally truncated
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• a few embryos are severely growth retarded
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• at E10.5 most unrotated, caudally truncated embryos have posterior abnormalities including cystic outgrowths
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• anterior neural tube is open in all embryos at E9.5 and E10.5
• however, neural tube closure does occur in the trunk
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• at E10.5, embryonic and maternal blood vessels fail to interdigitate
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• in some rare severely growth retarded embryos yolk sac vessel formation is defective
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• reduced number of spongiotrophoblasts in viable embryos at E10.5
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• about half as thick as in wild-type controls
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nervous system
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• strongly impaired neurogenesis in the spinal cord with residual neurons having a more medial location at E10.5
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• anterior neural tube is open in all embryos at E9.5 and E10.5
• however, neural tube closure does occur in the trunk
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• expression analysis indicates that neuronal differentiation is arrested or delayed but over all spatial organization is normal in the hindbrain at E10.5
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• virtually no sensory neurons are detected at E10.5
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cardiovascular system
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• at E10.5, embryonic and maternal blood vessels fail to interdigitate
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• the morphology of intermediate blood vessels and capillaries are severely abnormal and vessels of the cardinal vein plexus are reduced in number and appear disconnected from the cranial capillaries indicating impaired remodeling of the vasculature
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• in some rare severely growth retarded embryos yolk sac vessel formation is defective
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• cardiac malformations are seen in some rare severely growth retarded embryos
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• frequently seen in older embryos
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homeostasis/metabolism
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• frequently seen in older embryos
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growth/size/body
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• a few embryos are severely growth retarded
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cellular
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• the morphology of intermediate blood vessels and capillaries are severely abnormal and vessels of the cardinal vein plexus are reduced in number and appear disconnected from the cranial capillaries indicating impaired remodeling of the vasculature
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• strongly impaired neurogenesis in the spinal cord with residual neurons having a more medial location at E10.5
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