All Phenotypes Ddr1<tm1Wfv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddr1^tm1Wfv/Ddr1^tm1Wfv	either: (involves: (129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3038250
hm2	Ddr1^tm1Wfv/Ddr1^tm1Wfv	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767990
hm3	Ddr1^tm1Wfv/Ddr1^tm1Wfv	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:5432776
cx4	Ddr1^tm1Wfv/Ddr1^tm1Wfv Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4367117
cx5	Ddr1^tm1Wfv/Ddr1^tm1Wfv Ddr2^tm1Kln/Ddr2^tm1Kln	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767989

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:68368 )

• the mammary epithelium of virgin mice was hyperproliferative

abnormal mammary gland development ( J:68368 )

• the mutant mammary glands displayed enlarged terminal end buds due to aberrant ductal growth

abnormal mammary gland duct morphology ( J:68368 )

• the number of secondary ducts was increased, the ducts had wider lumens, and significantly larger amounts of extracellular matrix were deposited around the ducts

abnormal lactation ( J:68368 )

• during pregnancy, loss of encoded protein perturbed the lobuloalveolar proliferation and differentiation, resulting in a large number of alveoli that were unable to secrete milk

• the presence of normal levels of milk protein transcripts in mutant mammary gland suggests that protein translation was perturbed in the mutant tissue

growth/size/body

abnormal outer ear morphology ( J:68368 )

• a high percentage of homozygous mutant mice failed to control their ear movement: one or sometimes both ears were curled back towards the body

postnatal growth retardation ( J:68368 )

• homozygous mutant mice were viable but showed severe postnatal growth reduction

• adult homozygous mutant males were only about 10% smaller than wild-type mice, whereas females had a 35% lower body weight

• all organs were proportionally smaller in both sexes

hearing/vestibular/ear

abnormal outer ear morphology ( J:68368 )

• a high percentage of homozygous mutant mice failed to control their ear movement: one or sometimes both ears were curled back towards the body

reproductive system

failure of embryo implantation ( J:68368 )

• most homozygous mutant females were unable to give birth because developing blastocysts failed to implant into the uterine wall

skeleton

abnormal bone mineralization ( J:68368 )

• bone formation and mineralization, chondrocyte proliferation, apoptosis, and the morphology of the growth plates in the tibia and metatarsus appeared normal; however, mutants exhibited lack of proper mineralization of the fibula bone and a narrow pelvis

craniofacial

abnormal outer ear morphology ( J:68368 )

• a high percentage of homozygous mutant mice failed to control their ear movement: one or sometimes both ears were curled back towards the body

integument

increased mammary gland epithelial cell proliferation ( J:68368 )

• the mammary epithelium of virgin mice was hyperproliferative

abnormal mammary gland development ( J:68368 )

• the mutant mammary glands displayed enlarged terminal end buds due to aberrant ductal growth

abnormal mammary gland duct morphology ( J:68368 )

• the number of secondary ducts was increased, the ducts had wider lumens, and significantly larger amounts of extracellular matrix were deposited around the ducts

abnormal lactation ( J:68368 )

• during pregnancy, loss of encoded protein perturbed the lobuloalveolar proliferation and differentiation, resulting in a large number of alveoli that were unable to secrete milk

• the presence of normal levels of milk protein transcripts in mutant mammary gland suggests that protein translation was perturbed in the mutant tissue

cellular

increased mammary gland epithelial cell proliferation ( J:68368 )

• the mammary epithelium of virgin mice was hyperproliferative

Allelic Composition	Ddr1^tm1Wfv/Ddr1^tm1Wfv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr1^tm1Wfv mutation (0 available); any Ddr1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Skull comparison of Ddr1^tm1Wfv/Ddr1^tm1Wfv, Ddr2^tm1Kln/Ddr2^tm1Kln and Ddr2^tm1Kln/Ddr2⁺ mice

craniofacial

abnormal cranium morphology ( J:123719 )

• subtle differences in skull formation compared to wild-type that are detected using high-resolution flat-panel volume computed tomography, but not by visual inspection

skeleton

abnormal cranium morphology ( J:123719 )

• subtle differences in skull formation compared to wild-type that are detected using high-resolution flat-panel volume computed tomography, but not by visual inspection

Allelic Composition	Ddr1^tm1Wfv/Ddr1^tm1Wfv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr1^tm1Wfv mutation (0 available); any Ddr1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:101769 )

N	• homozygotes show no signs of edema, weight loss, abnormal fluid intake or uremia up to 9 months of age • no glomerulosclerosis, tubulointerstitial fibrosis or loss of nephrons is observed

increased urine protein level ( J:101769 )

• adult homozygotes exhibit a selective middle- to high-molecular proteinuria of up to 0.3 g/L relative to less than 0.05 g/L in control mice

• microelectrophoresis of urine indicates large amounts of albumin, transferrin, haptoglobin and immunoglobulins (IgA, IgG)

erythrocyturia ( J:101769 )

• urine microscopy revealed 1-5 erythrocytes and 0-2 acanthocytes per visual field at 6 months of age

abnormal podocyte slit diaphragm morphology ( J:101769 )

• a loss of slit diaphragm is noted in a significant number of podocyte foot processes within the areas of localized GBM thickening

• in contrast, the slit diaphragm is detected in nearly all areas with a normal GBM width

increased renal glomerulus basement membrane thickness ( J:101769 )

• EM revealed a localized, subepithelial, mushroom-like isodense thickening of the GBM, affecting 3.4% of the GBM relative to 1.2% in heterozygous and 0% in wild-type controls

• bulge-like protrusions of the GBM are found in all mice examined (3-9 months of age) and no increase over age is observed

abnormal renal tubule epithelium morphology ( J:101769 )

• a modest increase of intracellular vacuoles is noted in tubular epithelial cells relative to control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:101769 )

N	• homozygotes display normal serum urea levels up to 9 months of age

increased urine protein level ( J:101769 )

• adult homozygotes exhibit a selective middle- to high-molecular proteinuria of up to 0.3 g/L relative to less than 0.05 g/L in control mice

• microelectrophoresis of urine indicates large amounts of albumin, transferrin, haptoglobin and immunoglobulins (IgA, IgG)

erythrocyturia ( J:101769 )

• urine microscopy revealed 1-5 erythrocytes and 0-2 acanthocytes per visual field at 6 months of age

Allelic Composition	Ddr1^tm1Wfv/Ddr1^tm1Wfv Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr1^tm1Wfv mutation (0 available); any Ddr1 mutation (35 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:149015 )

• pronounced reduction in atherosclerotic plaques after 12 and 24 weeks on a high fat diet

• 50% reduction in plaque area in the descending aorta at 12 weeks

• 60% reduction in plaque area in the descending aorta at 24 weeks

• total collagen and elastin in plaques is elevated at 12 weeks

• total collagen and elastin in plaques is at control levels at 24 weeks

• increased synthesis and decreased degradation of collagen and elastin at 12 weeks

hematopoietic system

decreased macrophage cell number ( J:149015 )

• few macrophage in plaques at 12 weeks

• macrophage numbers in plaques similar to controls at 24 weeks

immune system

decreased macrophage cell number ( J:149015 )

• few macrophage in plaques at 12 weeks

• macrophage numbers in plaques similar to controls at 24 weeks

Allelic Composition	Ddr1^tm1Wfv/Ddr1^tm1Wfv Ddr2^tm1Kln/Ddr2^tm1Kln
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr1^tm1Wfv mutation (0 available); any Ddr1 mutation (35 available)
Ddr2^tm1Kln mutation (0 available); any Ddr2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal cranium morphology ( J:123719 )

• skull abnormalities

skeleton

abnormal cranium morphology ( J:123719 )

• skull abnormalities

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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