Phenotypes associated with this allele

• Allele Symbol: Six4^tm1Kwk
• Allele Name: targeted mutation 1, Kiyoshi Kawakami
• Allele ID: MGI:2388027
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Six4^tm1Kwk/Six4^tm1Kwk	involves: 129P2/OlaHsd * C57BL/6	MGI:3036367
cx2	Six1^tm1Kwk/Six1^tm1Kwk Six4^tm1Kwk/Six4^tm1Kwk	involves: 129P2/OlaHsd	MGI:3612545

Genotype
MGI:3036367

hm1

• Allelic Composition: Six4^tm1Kwk/Six4^tm1Kwk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:69010 )

• viable and fertile; no gross morphological or histological abnormalities, or defects in hearing ability were detected in homozygous mice

Genotype
MGI:3612545

cx2

• Allelic Composition: Six1^tm1Kwk/Six1^tm1Kwk; Six4^tm1Kwk/Six4^tm1Kwk
• Genetic Background: involves: 129P2/OlaHsd

mortality/aging

neonatal lethality, complete penetrance ( J:103002 )

• die soon after birth and show developmental defects in various organs

nervous system

abnormal dorsal root ganglion morphology ( J:103002 )

• exhibit developmental abnormalities of the dorsal root ganglia