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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Htttm1.1Tna
targeted mutation 1.1, Toshiharu Nagatsu
MGI:2388035
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Htttm1.1Tna/Htttm1.1Tna involves: 129P2/OlaHsd * C57BL/6J MGI:3699093
ht2
Htttm1.1Tna/Htt+ involves: 129P2/OlaHsd * C57BL/6J MGI:3699097


Genotype
MGI:3699093
hm1
Allelic
Composition
Htttm1.1Tna/Htttm1.1Tna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1.1Tna mutation (0 available); any Htt mutation (178 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• exhibit an increase in glial fibrillary acidic protein (GFAP)-positive cells in the globus pallidus and the striatum at 40 weeks of age, indicating astrocytosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:76017




Genotype
MGI:3699097
ht2
Allelic
Composition
Htttm1.1Tna/Htt+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1.1Tna mutation (0 available); any Htt mutation (178 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• exhibit an increase in glial fibrillary acidic protein (GFAP)-positive cells in the substantia nigra and the globus pallidus at 40 weeks of age, indicating astrocytosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:76017





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory