Phenotypes associated with this allele

• Allele Symbol: Cx3cl1^tm1Lira
• Allele Name: targeted mutation 1, Sergio A Lira
• Allele ID: MGI:2388041
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: 129S/SvEv * C57BL/6	MGI:2447466
hm2	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	involves: C57BL/6	MGI:4834193
hm3	Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	Not Specified	MGI:4833987
cx4	Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Ifc/Ccr2^tm1Ifc Cx3cl1^tm1Lira/Cx3cl1^tm1Lira	B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc	MGI:4833678

Genotype
MGI:2447466

hm1

• Allelic Composition: Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:68831 )

N • mice do not exhibit overt behavioral abnormalities

immune system

immune system phenotype ( J:68831 )

N • the lymph node cellular composition does not differ significantly from that of control mice

N • the responses of mutant mice to a variety of inflammatory stimuli, including thioglycolate, L. monocytogenes, KLH and DSS, are indistinguishable from those of control mice

nervous system

nervous system phenotype ( J:68831 )

N • histological analysis of their brains and many other tissues did not reveal any gross changes compared to controls

hematopoietic system

hematopoietic system phenotype ( J:68831 )

N • mice have normal hematological profiles, including red blood cell number and hematocrit, except for a decrease in the number of blood leukocytes expressing the cell surface marker F4/80

Genotype
MGI:4834193

hm2

• Allelic Composition: Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
• Genetic Background: involves: C57BL/6

immune system

decreased monocyte cell number ( J:145036 )

• Gr1^low monocytes are reduced compared to in wild-type mice

hematopoietic system

decreased monocyte cell number ( J:145036 )

• Gr1^low monocytes are reduced compared to in wild-type mice

Genotype
MGI:4833987

hm3

• Allelic Composition: Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
• Genetic Background: Not Specified

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:110266 )

• mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neuron loss compared with similarly treated wild-type mice

Genotype
MGI:4833678

cx4

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr2^tm1Ifc/Ccr2^tm1Ifc; Cx3cl1^tm1Lira/Cx3cl1^tm1Lira
• Genetic Background: B6.Cg-Apoe^tm1Unc Cx3cl1^tm1Lira Ccr2^tm1Ifc

cardiovascular system

decreased susceptibility to atherosclerosis ( J:153310 )

• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoe^tm1Unc homozygotes and Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

hematopoietic system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes

immune system

decreased monocyte cell number ( J:153310 )

• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoe^tm1Unc homozygotes

• however, levels are the same as in Apoe^tm1Unc Ccr2^tm1Ifc homozygotes