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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb3tm1Nwg
targeted mutation 1, Nicholas W Gale
MGI:2388046
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efnb3tm1Nwg/Efnb3tm1Nwg involves: 129 * C57BL/6 MGI:3026786
hm2
 		Efnb3tm1Nwg/Efnb3tm1Nwg involves: C57BL/6 MGI:3823254
hm3
 		Efnb3tm1Nwg/Efnb3tm1Nwg Not Specified MGI:2672002


Genotype
MGI:3026786
hm1
Allelic
Composition		 Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1Nwg mutation (0 available); any Efnb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:87398 )
N
• normal hippocampal architecture
reduced long-term potentiation ( J:87398 )
• reduced early LTP but no significant defects of basal synaptic transmission parameters or NMDA receptor component




Genotype
MGI:3823254
hm2
Allelic
Composition		 Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1Nwg mutation (0 available); any Efnb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:82479 )
• rabbit like gait

nervous system
abnormal motor neuron innervation pattern ( J:82479 )
• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side
abnormal corticospinal tract morphology ( J:82479 )
• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side
abnormal central pattern generator function ( J:82479 )
• lumbar segments of the spinal cords of neonates exhibit synchronous left-right ventral root activity instead of the left-right alternating activity observed in wild-type after NMDA and serotonin application




Genotype
MGI:2672002
hm3
Allelic
Composition		 Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1Nwg mutation (0 available); any Efnb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:68814 )
• mirrored limb movement resulting in a hopping locomotion

nervous system
abnormal corticospinal tract morphology ( J:68814 )
• axons aberrantly crossed the midline boundary of the spinal cord




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory