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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3cdtm1Tnr
targeted mutation 1, Martin Turner
MGI:2388047
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr B6.129S4-Pik3cdtm1Tnr MGI:3796440
hm2
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr involves: 129S4/SvJae MGI:3796437
hm3
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr involves: 129S4/SvJae * C57BL/6J MGI:7645242
cn4
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Ptentm2.1Ppp/Ptentm2.1Ppp
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 MGI:3796508
cx5
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr 		B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr MGI:3796518
cx6
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3796506
cx7
 		Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0 		involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi MGI:3796509


Genotype
MGI:3796440
hm1
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic
Background		 B6.129S4-Pik3cdtm1Tnr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:134324 )
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
decreased inflammatory response ( J:134324 )
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
• however, neutrophil migration in response to fMLP is normal

skeleton
decreased susceptibility to induced arthritis ( J:134324 )
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice




Genotype
MGI:3796437
hm2
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:79133 )
• splenic B220+ CDhi B cells are absent unlike in wild-type mice
decreased B-1 B cell number ( J:79133 )
• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice
decreased B-2 B cell number ( J:79133 )
• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age
decreased marginal zone B cell number ( J:79133 )
• CD21hi CD23lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice
abnormal B cell physiology ( J:113491 )
• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice
• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice
decreased B cell proliferation ( J:79133 , J:113491 )
• in response to anti-IgM, CD40 and IL-4 (J:79133)
• however, B cell proliferation response to LPS is normal (J:79133)
decreased IgG1 level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice
decreased IgG2a level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice
decreased IgG2b level ( J:79133 )
• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice
decreased IgG3 level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice
decreased IgM level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice
abnormal humoral immune response ( J:79133 )
• following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice

hematopoietic system
decreased B cell number ( J:79133 )
• splenic B220+ CDhi B cells are absent unlike in wild-type mice
decreased B-1 B cell number ( J:79133 )
• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice
decreased B-2 B cell number ( J:79133 )
• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age
decreased marginal zone B cell number ( J:79133 )
• CD21hi CD23lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice
abnormal B cell physiology ( J:113491 )
• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice
• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice
decreased B cell proliferation ( J:79133 , J:113491 )
• in response to anti-IgM, CD40 and IL-4 (J:79133)
• however, B cell proliferation response to LPS is normal (J:79133)
decreased IgG1 level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice
decreased IgG2a level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice
decreased IgG2b level ( J:79133 )
• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice
decreased IgG3 level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice
decreased IgM level ( J:79133 )
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice

cellular
decreased B cell proliferation ( J:79133 , J:113491 )
• in response to anti-IgM, CD40 and IL-4 (J:79133)
• however, B cell proliferation response to LPS is normal (J:79133)




Genotype
MGI:7645242
hm3
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet aggregation ( J:114310 )
• platelets exhibit slower shape change and decreased rate and amplitude of aggregation compared to wild-type platelets in response to submaximal concentrations of adenosine diphosphate or phorbol ester, or intermediate and high levels of collagen-related peptide

homeostasis/metabolism
abnormal platelet aggregation ( J:114310 )
• platelets exhibit slower shape change and decreased rate and amplitude of aggregation compared to wild-type platelets in response to submaximal concentrations of adenosine diphosphate or phorbol ester, or intermediate and high levels of collagen-related peptide




Genotype
MGI:3796508
cn4
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Ptentm2.1Ppp/Ptentm2.1Ppp
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:130950 )
N
• unlike in Pten deficient mice, B1 B cell numbers are normal in the spleen and peritoneum
abnormal class switch recombination ( J:130950 )
• defects in class switch recombination associated with Pten deficiency are partially reversed
increased marginal zone B cell number ( J:130950 )
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice

hematopoietic system
abnormal class switch recombination ( J:130950 )
• defects in class switch recombination associated with Pten deficiency are partially reversed
increased marginal zone B cell number ( J:130950 )
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice




Genotype
MGI:3796518
cx5
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic
Background		 B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Pik3cgtm1Pngr mutation (0 available); any Pik3cg mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:134324 )
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
impaired neutrophil recruitment ( J:134324 )
• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice
decreased susceptibility to induced arthritis ( J:134324 )
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
decreased inflammatory response ( J:134324 )
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:134324 )
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice

cellular
impaired neutrophil chemotaxis ( J:134324 )
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells

hematopoietic system
impaired neutrophil chemotaxis ( J:134324 )
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
impaired neutrophil recruitment ( J:134324 )
• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice




Genotype
MGI:3796506
cx6
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Pik3cgtm1Pngr mutation (0 available); any Pik3cg mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus lobule morphology ( J:125791 )
• corticomedullary differentiation is lost
thymus hypoplasia ( J:125791 )
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
abnormal T cell differentiation ( J:125791 )
• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
decreased T cell number ( J:125791 )
• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
decreased double-positive T cell number ( J:125791 )
• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
abnormal T cell physiology ( J:125791 )
• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells

hematopoietic system
abnormal thymus lobule morphology ( J:125791 )
• corticomedullary differentiation is lost
thymus hypoplasia ( J:125791 )
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
abnormal T cell differentiation ( J:125791 )
• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
decreased T cell number ( J:125791 )
• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
decreased double-positive T cell number ( J:125791 )
• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
abnormal T cell physiology ( J:125791 )
• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells

endocrine/exocrine glands
abnormal thymus lobule morphology ( J:125791 )
• corticomedullary differentiation is lost
thymus hypoplasia ( J:125791 )
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice




Genotype
MGI:3796509
cx7
Allelic
Composition		 Pik3cdtm1Tnr/Pik3cdtm1Tnr
Tg(BCL2)36Wehi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation (0 available); any Pik3cd mutation (45 available)
Tg(BCL2)36Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene

hematopoietic system
decreased follicular B cell number ( J:130950 )
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory