Phenotypes associated with this allele

• Allele Symbol: Apcs^tm1Smae
• Allele Name: targeted mutation 1, Shuichiro Maeda
• Allele ID: MGI:2388056
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apcs^tm1Smae/Apcs^tm1Smae	involves: 129S/SvEv * C57BL/6	MGI:3775480

Genotype
MGI:3775480

hm1

• Allelic Composition: Apcs^tm1Smae/Apcs^tm1Smae
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased autoantibody level ( J:71194 )

decreased susceptibility to endotoxin shock ( J:71194 )

• male mice exhibit reduced mortality compared to wild-type mice following treatment with LPS

renal/urinary system

renal/urinary system phenotype ( J:71194 )

N • unlike some mice homozygous for a null allele, mice do not develop glomerulonephritis

homeostasis/metabolism

amyloidosis ( J:79398 )

• following injection of emulsion, initially fewer mice develop amyloidosis compared to wild-type mice

• however, by day 18 post-injection a similar percentage of mice develop amuloidosis as in wild-type mice