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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-Jtm1Jkbv
targeted mutation 1, Aya Jakobovits
MGI:2388068
Summary 18 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv involves: 129P2/OlaHsd MGI:3802923
hm2
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv involves: 129P2/OlaHsd * C57BL/6 MGI:3802619
cx3
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0 		involves: 129P2/OlaHsd MGI:3802679
cx4
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0 		involves: 129P2/OlaHsd MGI:3802681
cx5
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv 		involves: 129P2/OlaHsd MGI:3802682
cx6
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0 		involves: 129P2/OlaHsd MGI:3802924
cx7
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv 		involves: 129P2/OlaHsd MGI:3802925
cx8
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0 		involves: 129P2/OlaHsd MGI:3802926
cx9
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@*)SALed/0 		involves: 129P2/OlaHsd MGI:3802928
cx10
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv 		involves: 129P2/OlaHsd MGI:3802934
cx11
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv 		involves: 129P2/OlaHsd MGI:3802935
cx12
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv 		involves: 129P2/OlaHsd MGI:3802936
cx13
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv 		involves: 129P2/OlaHsd MGI:3802937
cx14
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2BM)7Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd MGI:3810268
cx15
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2CM)2Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd MGI:3810269
cx16
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG1/2)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd MGI:3810270
cx17
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd MGI:3810271
cx18
 		Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/0 		involves: 129P2/OlaHsd * C57BL/6J MGI:3802734


Genotype
MGI:3802923
hm1
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type
arrested B cell differentiation ( J:137738 )
• B cell development is arrested at the transition between pro- to pre- B cells with cells accumulating at fraction B (CD43+ CD45+ HSA+ BP-1-) and terminally arresting at fraction C (CD43+ CD45+ HSAmed BP-1+)
absent mature B cells ( J:137738 )
• mature B cells are not found in the periphery

hematopoietic system
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type
arrested B cell differentiation ( J:137738 )
• B cell development is arrested at the transition between pro- to pre- B cells with cells accumulating at fraction B (CD43+ CD45+ HSA+ BP-1-) and terminally arresting at fraction C (CD43+ CD45+ HSAmed BP-1+)
absent mature B cells ( J:137738 )
• mature B cells are not found in the periphery




Genotype
MGI:3802619
hm2
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent B cells ( J:70038 )
• B cells are not found in the periphery
abnormal T cell number ( J:113083 )
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
decreased IgM level ( J:70038 )
• IgM is not detected in the sera

hematopoietic system
absent B cells ( J:70038 )
• B cells are not found in the periphery
abnormal T cell number ( J:113083 )
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
decreased IgM level ( J:70038 )
• IgM is not detected in the sera




Genotype
MGI:3802679
cx3
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
Tg(IGK@yK1)9.2CJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell morphology ( J:23827 )
• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain
increased late pro-B cell number ( J:23827 )
• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process
increased mature B cell number ( J:23827 )
• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-Jtm1Jkbv development
• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels
abnormal immunoglobulin level ( J:23827 )
• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation
• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans

immune system
abnormal B cell morphology ( J:23827 )
• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain
increased late pro-B cell number ( J:23827 )
• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process
increased mature B cell number ( J:23827 )
• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-Jtm1Jkbv development
• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels
abnormal immunoglobulin level ( J:23827 )
• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation
• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans




Genotype
MGI:3802681
cx4
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
Tg(IGK@yK1)9.2CJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell morphology ( J:23827 )
• 43% of B cells express human mu heavy chain and human kappa light chain
• 57% of B cells express human mu heavy chain and mouse lamda light chain
• no co-expression of human and mouse light chain is found
increased mature B cell number ( J:23827 )
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cells are found at a level 10% of that in wild-type mice
abnormal immunoglobulin level ( J:23827 )
• human antibodies occur in the sera of mice at 10 micrograms per ml
• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated

hematopoietic system
abnormal B cell morphology ( J:23827 )
• 43% of B cells express human mu heavy chain and human kappa light chain
• 57% of B cells express human mu heavy chain and mouse lamda light chain
• no co-expression of human and mouse light chain is found
increased mature B cell number ( J:23827 )
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cells are found at a level 10% of that in wild-type mice
abnormal immunoglobulin level ( J:23827 )
• human antibodies occur in the sera of mice at 10 micrograms per ml
• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated




Genotype
MGI:3802682
cx5
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type
absent mature B cells ( J:70620 , J:137738 )
• mature B cells are absent from the spleen and blood (J:70620)
• mature B cells are not found in the periphery (J:137738)
absent B cells ( J:23827 )
• B cells are not found in this mouse strain

hematopoietic system
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type
absent mature B cells ( J:70620 , J:137738 )
• mature B cells are absent from the spleen and blood (J:70620)
• mature B cells are not found in the periphery (J:137738)
absent B cells ( J:23827 )
• B cells are not found in this mouse strain




Genotype
MGI:3802924
cx6
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 30% of wild-type

hematopoietic system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- to 4- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 30% of wild-type




Genotype
MGI:3802925
cx7
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• immature circulating B cells are at levels that are 80% of normal
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 20% of the numbers found in wild-type
• these B cells express human mu heavy chain
• these mature B cells numbers are twice those found in Ihg-J null mice that are hemizygote for the transgene
decreased pre-B cell number ( J:137738 )
• large pre-B cells numbers in the bone marrow are 50% of wild-type
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu heavy chains are found in the sera at levels of 60 micrograms per ml

hematopoietic system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• immature circulating B cells are at levels that are 80% of normal
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 20% of the numbers found in wild-type
• these B cells express human mu heavy chain
• these mature B cells numbers are twice those found in Ihg-J null mice that are hemizygote for the transgene
decreased pre-B cell number ( J:137738 )
• large pre-B cells numbers in the bone marrow are 50% of wild-type
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu heavy chains are found in the sera at levels of 60 micrograms per ml




Genotype
MGI:3802926
cx8
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@yH2)J9.2Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137738 )
N
• the presence of the transgene prevents the arrest in B cell differentiation that occurs in Igh-Jtm1Jkbv homozygotes
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu or gamma2 heavy chains are found in the sera at levels of 200 micrograms per ml

hematopoietic system
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu or gamma2 heavy chains are found in the sera at levels of 200 micrograms per ml




Genotype
MGI:3802928
cx9
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@*)SALed/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Tg(IGH@*)SALed mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137738 )
N
• the presence of the transgene prevents the arrest in B cell differentiation that occurs in Igh-Jtm1Jkbv homozygotes
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain

hematopoietic system
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain




Genotype
MGI:3802934
cx10
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
Tg(IGK@yK1)9.2CJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 10% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 30% of wild-type

hematopoietic system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 10% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 30% of wild-type




Genotype
MGI:3802935
cx11
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
Tg(IGK@yK1)9.2CJkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 70% of wild-type
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 150 and 120 micrograms per ml, respectively

hematopoietic system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• these B cells express human mu heavy chain
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 70% of wild-type
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 150 and 120 micrograms per ml, respectively




Genotype
MGI:3802936
cx12
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH1)2BJkbv mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 70% of wild-type

hematopoietic system
abnormal B cell differentiation ( J:137738 )
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
decreased immature B cell number ( J:137738 )
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
increased late pro-B cell number ( J:137738 )
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
decreased mature B cell number ( J:137738 )
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
decreased pre-B cell number ( J:137738 )
• pre-B cells numbers in the bone marrow are 70% of wild-type




Genotype
MGI:3802937
cx13
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH2)J9.2Jkbv mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137738 )
N
• the presence of the transgene prevents the arrest in B cell differentiation that occurs in Igh-Jtm1Jkbv homozygotes
decreased immature B cell number ( J:137738 )
• the levels of immature B cells found in circulation are 70% that found in wild-type mice
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 300 and 530 micrograms per ml, respectively

hematopoietic system
decreased immature B cell number ( J:137738 )
• the levels of immature B cells found in circulation are 70% that found in wild-type mice
decreased mature B cell number ( J:137738 )
• the levels of mature B cells found in the spleen are 50% and 70% respectively, of those found in wild-type mice
• these B cells express human mu heavy chain
abnormal immunoglobulin level ( J:137738 )
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 300 and 530 micrograms per ml, respectively




Genotype
MGI:3810268
cx14
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2BM)7Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH2BM)7Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:139792 )
• mice have 60-80% the number of B cells as wild-type mice
abnormal immunoglobulin level ( J:139792 )
• unimmunized mice produce significant levels of human IgM and IgG1
• IgM levels in sera ranged from 110-140 micrograms/ml
• IgG1 levels in sera ranged from 172-298 micrograms/ml
• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences

hematopoietic system
decreased B cell number ( J:139792 )
• mice have 60-80% the number of B cells as wild-type mice
abnormal immunoglobulin level ( J:139792 )
• unimmunized mice produce significant levels of human IgM and IgG1
• IgM levels in sera ranged from 110-140 micrograms/ml
• IgG1 levels in sera ranged from 172-298 micrograms/ml
• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences




Genotype
MGI:3810269
cx15
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2CM)2Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH2CM)2Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:139792 )
• mice have 80-100% the number of B cells as wild-type mice
abnormal immunoglobulin level ( J:139792 )
• unimmunized mice produce significant levels of human IgM and IgG2
• IgM levels in sera ranged from 27.3-109.4 micrograms/ml
• IgG2 levels in sera ranged from 37.6-665.3 micrograms/ml
• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences

hematopoietic system
decreased B cell number ( J:139792 )
• mice have 80-100% the number of B cells as wild-type mice
abnormal immunoglobulin level ( J:139792 )
• unimmunized mice produce significant levels of human IgM and IgG2
• IgM levels in sera ranged from 27.3-109.4 micrograms/ml
• IgG2 levels in sera ranged from 37.6-665.3 micrograms/ml
• immunizing mice with human antigens leads to production of antigen-specific antibodies with human sequences




Genotype
MGI:3810270
cx16
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG1/2)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yHG1/2)1Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG1 antibodies with human sequences

hematopoietic system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG1 antibodies with human sequences




Genotype
MGI:3810271
cx17
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yHG4)1Amgn mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG4 antibodies with human sequences

hematopoietic system
abnormal immunoglobulin level ( J:139792 )
• immunizing mice with human antigens leads to production of antigen-specific IgG4 antibodies with human sequences




Genotype
MGI:3802734
cx18
Allelic
Composition		 Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation (0 available); any Igh-J mutation (13 available)
Igkctm1Jkbv mutation (0 available); any Igkc mutation (9 available)
Tg(IGH@yH2)J9.2Jkbv mutation (0 available)
Tg(IGK@yK2)J23.1Jkbv mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell morphology ( J:70620 )
• all B cells express human IgM and high levels of B220
• about 80% of B cells exclusively express human kappa light chain
• only 15% of B cells express endogenous mouse lambda mouse chain
abnormal immunoglobulin heavy chain V(D)J recombination ( J:70620 )
• productive rearrangement of the VDJ segments of the Tg(IGHyH2)J9.2Jkbv transgene occurs in B cells
• the V gene segments used are widely distributed in the variable region of the transgene with predominant usage similar to what is observed in humans
• J segment usage also resembles usage in human B cells
abnormal immunoglobulin light chain V-J recombination ( J:70620 )
• productive rearrangement of the VJ segments of the Tg(IGKyK2)J23.1Jkbv transgene occurs in B cells
• V and J gene segment usage resembles what is observed in human B cells
increased mature B cell number ( J:70620 )
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cell numbers are 60% of that found in wild-type mice
abnormal immunoglobulin level ( J:70620 )
• antibodies containing human immunoglobulin chains are present in the sera
• concentrations of human mu and gamma2 heavy chains, and kappa light chains are 700, 600, and 800 micrograms per ml, respectively
• after immunization with antigen, IgG2 levels increase to 2.5 mg per ml
• high affinity human antibodies can be generated by immunizing mice with human antigen

hematopoietic system
abnormal B cell morphology ( J:70620 )
• all B cells express human IgM and high levels of B220
• about 80% of B cells exclusively express human kappa light chain
• only 15% of B cells express endogenous mouse lambda mouse chain
abnormal immunoglobulin heavy chain V(D)J recombination ( J:70620 )
• productive rearrangement of the VDJ segments of the Tg(IGHyH2)J9.2Jkbv transgene occurs in B cells
• the V gene segments used are widely distributed in the variable region of the transgene with predominant usage similar to what is observed in humans
• J segment usage also resembles usage in human B cells
abnormal immunoglobulin light chain V-J recombination ( J:70620 )
• productive rearrangement of the VJ segments of the Tg(IGKyK2)J23.1Jkbv transgene occurs in B cells
• V and J gene segment usage resembles what is observed in human B cells
increased mature B cell number ( J:70620 )
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cell numbers are 60% of that found in wild-type mice
abnormal immunoglobulin level ( J:70620 )
• antibodies containing human immunoglobulin chains are present in the sera
• concentrations of human mu and gamma2 heavy chains, and kappa light chains are 700, 600, and 800 micrograms per ml, respectively
• after immunization with antigen, IgG2 levels increase to 2.5 mg per ml
• high affinity human antibodies can be generated by immunizing mice with human antigen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory