Phenotypes associated with this allele

• Allele Symbol: Sst^tm1Low
• Allele Name: targeted mutation 1, Malcolm J Low
• Allele ID: MGI:2388093
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sst^tm1Low/Sst^tm1Low	B6.129P2-Sst^tm1Low	MGI:3814088

Genotype
MGI:3814088

hm1

• Allelic Composition: Sst^tm1Low/Sst^tm1Low
• Genetic Background: B6.129P2-Sst^tm1Low

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to age related obesity ( J:70016 )

• males exhibit gradual increase in body weight due to mild obesity after 18 months of age

nervous system

abnormal nervous system electrophysiology ( J:108920 )

• frequency of spontaneous extracellular bursting in hippocampal slices is lower than in wild-type slices

• application of somatostatin-14 (SRIF) to slices has no effect whereas treatment decreases frequency of spontaneous bursting in wild-type slices; application of CYN, a Sst-receptor agonist, increases frequency in mutant slices but has no effect in wild-type

abnormal excitatory postsynaptic potential ( J:108920 )

• application of CYN significantly increased peak amplitude of NMDA- and AMPA-mediated EPSPs in mutants but causes decreased amplitudes in wild-type slices

abnormal inhibitory postsynaptic potential ( J:108920 )

• in cells in wild-type hippocampal slices, application of CYN significantly increases amplitudes of GABA-A mediated IPSCs but CYN has no effect on mutant slices

homeostasis/metabolism

increased circulating gastrin level ( J:126384 )

• basal gastrin levels are elevated relative to wild-type; upon H.felis infection, levels are significantly elevated compared to infected wild-type controls

abnormal circulating pituitary hormone level ( J:70016 )

• growth hormone levelsshow significantly elevated median levels compared to wild-type

decreased growth hormone level ( J:70016 )

• pituitary growth hormone content is reduced by 50% compared to wild-type

immune system

immune system phenotype ( J:126384 )

N • colonization by H.felis in the stomach is inhibited by Il4 treatment in wild-type and Sst-deficient mice