Phenotypes associated with this allele

• Allele Symbol: Slc22a3^tm1Dpb
• Allele Name: targeted mutation 1, Denise P Barlow
• Allele ID: MGI:2388117
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc22a3^tm1Dpb/Slc22a3^tm1Dpb	involves: 129P2/OlaHsd	MGI:5310794
hm2	Slc22a3^tm1Dpb/Slc22a3^tm1Dpb	involves: 129P2/OlaHsd * FVB/N	MGI:3029991

Genotype
MGI:5310794

hm1

• Allelic Composition: Slc22a3^tm1Dpb/Slc22a3^tm1Dpb
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice

abnormal dopamine level ( J:180517 )

• paraquat-treated mice exhibit decreased striatal dopamine but increased dopamine overflow compared with similarly treated wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice

Genotype
MGI:3029991

hm2

• Allelic Composition: Slc22a3^tm1Dpb/Slc22a3^tm1Dpb
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

mortality/aging ( J:69978 )

N • homozygotes were born at the expected Mendelian ratio and lived a normal life span

behavior/neurological

behavior/neurological phenotype ( J:69978 )

N • general behavior was normal

N • maternal nurturing behavior of females was normal

cardiovascular system

cardiovascular system phenotype ( J:69978 )

N • hearts were histologically normal

growth/size/body

growth/size/body region phenotype ( J:69978 )

N • mice were of normal size

reproductive system

reproductive system phenotype ( J:69978 )

N • placentas were histologically normal

N • both males and females were fertile and litters of normal size were produced

nervous system

nervous system phenotype ( J:69978 )

N • noradrenalin and dopamine levels in embryos, placentas, and heart were not abnormal statistically although they were reduced by 50% - levels were highly variable