Phenotypes associated with this allele

• Allele Symbol: Mnat1^tm1Tpm
• Allele Name: targeted mutation 1, Tomi P Makela
• Allele ID: MGI:2388119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mnat1^tm1Tpm/Mnat1^tm1Tpm	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3577363

Genotype
MGI:3577363

hm1

• Allelic Composition: Mnat1^tm1Tpm/Mnat1^tm1Tpm
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:69926 )

• lethality probably after implantation but before gastrulation

• most homozygotes alive at E4.0, none alive at E7.5

embryo

abnormal embryonic tissue morphology ( J:69926 )

• early cell divisions dependent on the presence of maternal gene product

inner cell mass degeneration ( J:69926 )

• proliferative inner cell mass cells and thus endodermal cells fail to develop