All Phenotypes Slc31a1<tm1Djt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc31a1^tm1Djt
targeted mutation 1, Dennis J Thiele
MGI:2388121

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc31a1^tm1Djt/Slc31a1^tm1Djt	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3771159
ht2	Slc31a1^tm1Djt/Slc31a1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3771160

Allelic Composition	Slc31a1^tm1Djt/Slc31a1^tm1Djt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc31a1^tm1Djt mutation (0 available); any Slc31a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69897 )

• mice are not recovered after E10.5

embryo

failure of initiation of embryo turning ( J:69897 )

• by E9.5

abnormal mesoderm development ( J:69897 )

• at E7.5, mesoderm is poorly developed

decreased embryo size ( J:69897 )

• at E7.5

abnormal mesenchyme morphology ( J:69897 )

• at E9.5, mesenchyme cell formation is severely diminished

abnormal embryonic neuroepithelium morphology ( J:69897 )

• at E7.5, neural ectoderm is poorly developed

delayed neural tube closure ( J:69897 )

• at E9.5

growth/size/body

decreased embryo size ( J:69897 )

• at E7.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:69897 )

• at E7.5, neural ectoderm is poorly developed

delayed neural tube closure ( J:69897 )

• at E9.5

Allelic Composition	Slc31a1^tm1Djt/Slc31a1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc31a1^tm1Djt mutation (0 available); any Slc31a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal copper level ( J:69897 )

• copper levels in the spleen and brain are decreased (spleen, 0.6+/-0.1 compared to 1.0+/-0.4 in wild-type mice; brain, 1.7+/-0.2 compared to 3.2+/-0.1 in wild-type mice)

decreased liver iron level ( J:69897 )

• iron levels in the liver are decreased (67.8+/-9.0 compared to 81.2+/-10.6 in wild-type mice)

liver/biliary system

decreased liver iron level ( J:69897 )

• iron levels in the liver are decreased (67.8+/-9.0 compared to 81.2+/-10.6 in wild-type mice)

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