Analysis Tools
mortality/aging
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• though present in reduced numbers before E9.5, no mice are recovered after E9.5
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embryo
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• at E6.5 and E7.5, mice exhibit truncated embryonic tissue and appear more fragile than wild-type mice
• by E8.5, embryonic tissues have atrophied and embryos retain large extra-embryonic regions
• apoptosis of embryonic tissue is increased relative to in wild-type mice
• collagen IV staining shows that the basement membrane of embryonic regions is discontinuous and of variable thickness
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thin endoderm
(
J:69862
)
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• by E7.5, endoderm is sparse
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• at E7.5
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• at E7.5
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• at E7.5, Reichert's membrane is thin and discontinuous
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• at E7.5
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cardiovascular system
hemorrhage
(
J:69862
)
|
• at E7.5 and E8.5, mice exhibit whole body hemorrhage due to invasion of maternal blood
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cellular
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• collagen IV staining shows that the basement membrane of embryonic regions is discontinuous and of variable thickness
• however, the basement membrane of extra-embryonic regions and the ectoplacenta is normal
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