Analysis Tools
mortality/aging
|
• mice died between 6 weeks and 6 months of age
|
behavior/neurological
|
• mice exhibited greater kaniate-induced seizure susceptibility than controls
|
limb grasping
(
J:69504
)
|
• animals exhibited a limb clasping reflex when lifted by the legs; control mice extended their legs
|
growth/size/body
|
• growth defects were noted by 2 weeks of age; most mice did not increase in size after 5 weeks of age
|
reproductive system
 |
• males failed to produce litters despite the presence of sperm in the seminiferous tubules
|
nervous system
|
• mice exhibited greater kaniate-induced seizure susceptibility than controls
|
|
• a progressive reduction in the number of pyramidal cells was seen in the CA3 region of the hippocampus
|
