All Phenotypes Rxfp2<tm1Aia> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rxfp2^tm1Aia
targeted mutation 1, Alexander I Agoulnik
MGI:2388129

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd	MGI:5473316
hm2	Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2388134
cn3	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Rarb-cre)1Bhr/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL	MGI:5473318
cn4	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL	MGI:5473320
cn5	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(ACTA1-cre)79Jme/0	involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N * SJL	MGI:5473317
cn6	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Stra8-icre)1Reb/0	involves: 129S7/SvEvBrd * C57BL/6N * FVB/NJ	MGI:5473319
cx7	Rxfp1^tm1Aia/Rxfp1^tm1Aia Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3054971
cx8	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141501
cx9	Rxfp2^tm1Aia/crsp	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3603529

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

reproductive system

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

reproductive system

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

arrest of spermatogenesis ( J:79124 )

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

abnormal inguinal canal morphology ( J:79124 )

• inguinal canal fails to form

male infertility ( J:79124 )

endocrine/exocrine glands

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

skeleton

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:79124

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Rarb-cre)1Bhr/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)
Rxfp2^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Rxfp2 mutation (53 available)
Tg(Rarb-cre)1Bhr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

endocrine/exocrine glands

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal testis position

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(ACTA1-cre)79Jme/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal testis position

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Stra8-icre)1Reb/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6N * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal reproductive organ abnormalities

Allelic Composition	Rxfp1^tm1Aia/Rxfp1^tm1Aia Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1^tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased nipple size ( J:92627 )

• mutant females have small nipples

cryptorchism ( J:92627 )

• intra-abdominal cryptorchism is seen

• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion

abnormal lactation ( J:92627 )

• about 2/3 of the mutant females are unable to nurse pups

reproductive system

cryptorchism ( J:92627 )

• intra-abdominal cryptorchism is seen

• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion

respiratory system

respiratory system phenotype ( J:92627 )

N	• no significant fibrosis is seen in the lungs

integument

decreased nipple size ( J:92627 )

• mutant females have small nipples

abnormal lactation ( J:92627 )

• about 2/3 of the mutant females are unable to nurse pups

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (31 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• female mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

abnormal uterus physiology ( J:174719 )

• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

growth/size/body

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

Allelic Composition	Rxfp2^tm1Aia/crsp
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
crsp mutation (0 available); any crsp mutation (0 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

reproductive system

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

arrest of spermatogenesis ( J:79124 )

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

absent male inguinal canal ( J:79124 )

• inguinal canal fails to form

male infertility ( J:79124 )

endocrine/exocrine glands

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

skeleton

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:79124

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24