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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr132tm1Witt
targeted mutation 1, Owen N Witte
MGI:2388138
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr132tm1Witt/Gpr132tm1Witt B6.129X1-Gpr132tm1Witt MGI:3576045
hm2
 		Gpr132tm1Witt/Gpr132tm1Witt involves: 129X1/SvJ * BALB/c MGI:3639677
cx3
 		Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her 		B6.129-Ldlrtm1Her Gpr132tm1Witt MGI:3639678


Genotype
MGI:3576045
hm1
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background		 B6.129X1-Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline

cellular
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline

hematopoietic system
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline




Genotype
MGI:3639677
hm2
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background		 involves: 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
increased immunoglobulin level ( J:69473 )
• kappa and lambda light chain levels elevated
increased IgA level ( J:69473 )
• in older mice
increased IgG1 level ( J:69473 )
• elevated IgG1 levels in older mice
abnormal immune system organ morphology ( J:69473 )
• although normal in young mice, after 1 year of age, secondary lymph nodes become grossly enlarged
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes
abnormal lymph node morphology ( J:69473 )
• 2-3X increase of B220+ B lymphocytes
• disrupted architecture
• 3-6X increase of single positive T lymphocytes
enlarged inguinal lymph nodes ( J:69473 )
• rarely is enlarged in young mice
increased anti-nuclear antigen antibody level ( J:69473 )
• increased autoantibodies to nuclear antigens
increased inflammatory response ( J:69473 )
• heavy infiltration of lymphocytes into various organs in older mice
liver inflammation ( J:69473 )
• clusters of lymphocytes in liver parenchyma
kidney inflammation ( J:69473 )
• immunoglobulin complex deposited in glomeruli
lung inflammation ( J:69473 )
• perivascular and interalveolar infiltration of mononuclear cells

growth/size/body
cachexia ( J:69473 )
• start to show signs of wasting at 15-16 months of age
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes

hematopoietic system
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
increased immunoglobulin level ( J:69473 )
• kappa and lambda light chain levels elevated
increased IgA level ( J:69473 )
• in older mice
increased IgG1 level ( J:69473 )
• elevated IgG1 levels in older mice

liver/biliary system
liver inflammation ( J:69473 )
• clusters of lymphocytes in liver parenchyma

respiratory system
lung inflammation ( J:69473 )
• perivascular and interalveolar infiltration of mononuclear cells

renal/urinary system
kidney inflammation ( J:69473 )
• immunoglobulin complex deposited in glomeruli

cellular
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autoimmune disease DOID:417 OMIM:109100
 J:69473




Genotype
MGI:3639678
cx3
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Ldlrtm1Her Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (25 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:100498 )
• area in lesions occupied by macrophage is significantly increased
• reduced collagen content
• decreased apoptosis of macrophage in lesions

immune system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

cellular
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

hematopoietic system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory